3 European Projects Found
Searched on 125080 European Projects
FINISHED
Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures (NOTOX)
Start date: Jan 1, 2011, End date: Dec 31, 2015,
"NOTOX will develop and establish a spectrum of systems biological tools including experimental and computational methods for i) organotypic human cell cultures suitable for long term toxicity testing and ii) the identification and analysis of pathways of toxicological relevance. NOTOX will initially use available human HepaRG and primary liver cells as well as mouse small intestine cultures in 3D ...
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13
Partners Participants
FINISHED
Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems (DETECTIVE)
Start date: Jan 1, 2011, End date: Dec 31, 2015,
"Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes. An integrated research strategy for the replacement of animal tests needs to comprise the development of biomarkers of long-term toxicity in human target cells. To this aim, the DETECTIVE project will set up a scr ...
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15
Partners Participants
FINISHED
The Body-on-a-Chip (BoC) (BOC)
Start date: Jun 1, 2012, End date: May 31, 2015,
High attrition and failures rates in pharmaceutical and biotechnological drug development require a paradigm change towards more physiological human cell-based assays at an early time point in the process. The central idea of this proposal is to develop a versatile and reconfigurable pharmaceutical screening technology platform that relies on organotypic three-dimensional spherical microtissues. T ...
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