Search for European Projects

7 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors (REQUITE)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

...apy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million received radiotherapy. In the long ...
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 15

 FINISHED 

Mechanisms of Mismatch repair inactivation and identification of genes suppressing mutations (iMMR)

Start date: Apr 1, 2014, End date: Mar 31, 2018,

...ore the stability of the genome, relies on the DNA Mismatch repair (MMR) pathway, which recognizes DNA replication errors and promotes repair by an excision and re-synthesis mechanism. Mutations that inactivate MMR are associated to Lynch Syndrome, an early-onset cancer disorder characterized by accumulation of mutations at repetitive sequences or microsatellite instability (MSI). Interestingly, a ...
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 1

 FINISHED 

Defining the Impact of Chromosome Instability in Tumor Initiation, Maintenance and Relapse (MADCIN)

Start date: Feb 1, 2012, End date: Jan 31, 2018,

Chromosomal instability (CIN), the inability to correctly segregate sister chromatids during mitosis, is a hallmark of cancer cells. Overexpression of the mitotic checkpoint protein Mad2, commonly found in human tumors, leads to CIN and the development of aneuploid tumors in mouse models. However, recent observations from various laboratories suggest that aneuploidy can promote or suppress tumorig ...
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 2

 FINISHED 

Unlocking the potential of ultra-high-field MRI through manipulation of radiofrequency excitation fields in human tissue (MRexcite)

Start date: May 1, 2012, End date: Apr 30, 2017,

... often counteracted by these unresolved technical hurdles. 7T MRI cannot be considered for routine clinical use or even effectively evaluated for such use until these hurdles have been overcome.Preliminary research indicates that these effects can be addressed by use of parallel transmission strategies. The goal of the proposed project is to develop a highly optimized multi-channel transmit/receiv ...
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 2

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Identifying and characterising transmembrane transporters of tryptophan and kynurenine in normal and cancerous brain tissue (KP Transport)

Start date: Sep 1, 2014, End date: Aug 31, 2016,

The catabolism of the essential amino acid tryptophan (Trp) by tumour cells expressing either IDO1/2 or TDO has been associated with malignant tumour progression and poor patient survival. Expression of these rate-limiting genes leads to both depletion of Trp and accumulation of the Trp breakdown product kynurenine (Kyn) in the tumour microenvironment. Kyn has recently been shown to act as a lig ...
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 1

 FINISHED 

Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes (DIABAT)

Start date: Oct 1, 2011, End date: Sep 30, 2015,

"The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the ...
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 22

 FINISHED 

Regulation of Argonaute-2 and miRNA-dependent mRNA decay in response to oxidative stress and DNA damage (mirnaAGOddr)

Start date: Mar 7, 2012, End date: Mar 6, 2014,

Cells respond to extracellular stress by inducing specific intracellular programs through the activation of stress kinase signalling pathways. Stress responses are associated with the phosphorylation of particular substrates implicated in restoring homeostasis and cell integrity. Oncogene activation has also been shown to generate replicative DNA damage, activate the DNA Damage Response (DDR) and ...
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 1