Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

European Human Biomonitoring Initiative (HBM4EU)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

The overarching goal of the European Human Biomonitoring Initiative (HBM4EU) is to generate knowledge to inform the safe management of chemicals and so protect human health. We will use human biomonitoring to understand human exposure to chemicals and resulting health impacts and will communicate with policy makers to ensure that our results are exploited in the design of new chemicals policies an ...
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 43

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Early-life stressors and LifeCycle health (LIFECYCLE)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer an unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of non-communicable diseases. LIFECYCLE will establish the Eur ...
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EUROlinkCAT: Establishing a linked European Cohort of Children with Congenital Anomalies (EUROlinkCAT)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Over 130,000 children born in Europe every year will have a congenital anomaly (CA; birth defect). These CAs, which are often rare diseases, are a major cause of infant mortality, childhood morbidity and long-term disability. EUROCAT is an established European network of population-based registries for the epidemiologic surveillance of CAs. EUROlinkCAT will use the EUROCAT infrastructure to suppor ...
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ORTHOpedic randomized clinical trial with expanded bone marrow MSC and bioceramics versus autograft in long bone nonUNIONs (ORTHOUNION)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Current orthopaedic treatments permit spontaneous bone regeneration to unite and heal 90% bone injuries. Non-union associates pain and disability, often requiring biological enhancement. Regenerative medicine research suggests to the general public that alternative treatments based on advanced therapy medicinal products (ATMP) are already available. However, early clinical trials only explore its ...
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 13

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Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Start date: Jan 1, 2015, End date: Dec 31, 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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NMDA receptor diversity: from molecular dynamics to synaptic physiopathology (NMDADYN)

Start date: Nov 1, 2016, End date: Oct 31, 2021,

NMDA receptors (NMDARs) have long fascinated neuroscientists with their distinct biophysical properties and critical roles in neuronal communication and plasticity. Recent studies have revealed that these glutamate-gated ion channels are more complex than initially thought, undergoing tight subunit-specific regulation by an array of endogenous modulators and existing as multiple subtypes, each wit ...
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 1

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NEUROBIOLOGY OF EPILEPSY GENES (EPITOR)

Start date: Oct 1, 2016, End date: Sep 30, 2021,

Ion channel genes have long been linked to Mendelian focal epilepsies, but my recent finding of frequent mutations in DEPDC5 opens completely new perspectives. DEPDC5 is an inhibitor of the mTORC1 (mammalian target of rapamycin) signaling pathway, the master regulator of cell proliferation and growth. Mutations of this gene are found in a wide spectrum of focal epilepsy syndromes, with or without ...
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 1

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Cofactor Binding Antibodies – Basic Aspects and Therapeutic Innovations (CoBABATI)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

The immune repertoire of healthy individuals contains a fraction of antibodies (Abs) that are able to bind with high affinity various endogenous or exogenous low molecular weight compounds, including cofactors essential for the aerobic life, such as riboflavin, heme and ATP. Despite identification of cofactor-binding Abs as a constituent of normal immune repertoires, their fundamental characterist ...
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 1

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Memory and innate-like B-cell subsets: deciphering a multi-layered B-cell response in mice and humans (B-response)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

B cells are the main actors of successful vaccines, and their protective capacity relies on several subsets with innate-like and memory properties that fulfill different effector functions. In the present project, we wish to develop approaches in both mice and humans, to confront the similarities and the differences of their B cell responses. The three aims proposed are:1) To study the different B ...
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 1

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Cell intrinsic control of CD4 T cell differentiation by cytosolic DNA sensing pathways (CD4DNASP)

Start date: Aug 1, 2016, End date: Jul 31, 2021,

This proposal aims to investigate the role of cytosolic DNA sensing pathways in CD4 T cell differentiation.Cellular host defense to pathogens relies on the detection of pathogen-associated molecular patterns including deoxyribonucleic acid (DNA), which can be recognized by host myeloid cells through Toll-like receptor (TLR) 9 binding. Recent evidence however suggests that innate immune cells can a ...
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 1

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Biological Determinants of ILC Reactivity for Immune Responses in Health and Disease (ILC_REACTIVITY)

Start date: Aug 1, 2016, End date: Jul 31, 2021,

Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α and interferon-γ) and thereby contribute to the immediate, first-line immune defense against viral, bacterial, and parasitic infections. ILCs include the previous ...
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 1

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RECAP: Research on European Children and Adults born Preterm (RECAP)

Start date: Jan 1, 2017, End date: Mar 31, 2021,

The project’s overall aim is to improve the health, development and quality of life of children and adults born very preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) – approximately 50 000 births each year in Europe – by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and the ...
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BIOlogical therapy CYCLEs towards tailored, needs-driven, safer and cost-effective management of Crohn’s disease (BIOCYCLE)

Start date: Apr 1, 2015, End date: Mar 31, 2021,

"The BIOCYCLE Project proposes to test and critically assess the benefits and risks of an innovative regimen for improving the treatment of Crohn’s disease (CD), a chronic immune-mediated inflammatory disease affecting the gastro-intestinal tract of an increasing number of patients. Currently, the combination of anti-TNFα monoclonal antibodies and immunosuppressants used without interruption is th ...
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 13

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New siRNA Nanotherapy for Inflammatory Bowel Diseases, targeting Janus kinase 3 (NEW DEAL)

Start date: Feb 1, 2017, End date: Jan 31, 2021,

Inflammatory bowel diseases (IBD) are the second most common immune-mediated disorders in Europe, affecting more particularly young people. The current therapies, including antibodies, show three main drawbacks: efficacy, tolerability and convenience. NEW DEAL solution will offer radical therapeutic progress for all IBD patients, thanks to the improved efficacy and increased safety of the specific ...
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 11

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SPIDIA for Personalized Medicine - Standardisation of generic Pre-analytical procedures for In-vitro DIAgnostics for Personalized Medicine (SPIDIA4P)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

...poses a coordination and support action that reunites 19 highly experienced partners in international standardisation for in vitro diagnostics, coming from private industry including SMEs, public institutions and from one official European Standards Organisation. This strong consortium is balanced and empowered to maximise the impacts of in vitro diagnostics on personalised medicine.
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Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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Paediatric Clinical Research Infrastructure Network (PedCRIN)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group ...
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 16

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Distinctive characterization of regulatory plasma cells and pro-inflammatory B cells in immunity: their origins, molecular properties, and cellular fates. (PREG-LAB)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

B cells can act both as negative regulators and as drivers of immunity through the production of cytokines. Through secretion of interleukin (IL)-10 B cells inhibited immunity in autoimmune and infectious diseases. For instance, IL-10 from B cells drove complete recovery from disease in experimental autoimmune encephalomyelitis (EAE), the primary animal model for multiple sclerosis (MS), while a l ...
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 1

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Investigating the impact of meditation training on mental health and wellbeing in the ageing population (MEDIT-AGEING)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

As the number of older people in Europe grows, increasing healthy life years is a priority. Cognitive decline, dementia (e.g. Alzheimer’s disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that lifestyle factors and meditation practice have the potent ...
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 12

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Cell circuits as targets and biomarkers for liver disease and cancer prevention (HEPCIR)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Chronic liver diseases such as liver cirrhosis and hepatocellular carcinoma (HCC) are major challenges for global health. HCC is the second leading and fastest rising cause of cancer death worldwide. The limited availability of therapeutic options reflects our poor understanding of the molecular and clinical mechanisms involved in progression of liver disease. Chronic hepatitis C virus (HCV) infec ...
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 2

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European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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Nano Voltage Sensors (NVS)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

To understand how the brain works, tools need to be developed that will allow neuroscientists to investigate how interactions between individual neurons lead to emergent networks. Towards this goal, we will develop targetable voltage sensing nanorods that self-insert into the cell membrane and optically and non-invasively record action potentials at the single particle and nanoscale level, at mult ...
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 4

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Targeting IRE1 in disease (INSPIRED)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

The overarching objective of this Interfere to Suppress or Promote IRE1 (INSPIRED) RISE programme is to drive research and innovation in cell stress and drug development for cancer and neurodegenerative diseases by forming an interdisciplinary and intersectoral network of experts with strong, dynamic and productive interactions. The partners will work together, each bringing their unique expertise ...
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 4

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Scanning probe microscopies for nanoscale fast, tomographic and composition imaging (SPM2.0)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

...ntly in a leading position, in order to enforce its further development and its quick and wide commercialization and implementation in public and private research centers and industrial and metrology institutions. The researchers of the network will acquire a solid state-of-the-art multidisciplinary scientific training in this field of research, covering from basic science to industrial applicatio ...
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 10

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Small vessel diseases in a mechanistic perspective: Targets for InterventionAffected pathways and mechanistic exploitation for prevention of stroke and dementia (SVDs-at-target)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

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From mechanical stress to vascular fate (MechanoFate)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

In the vascular system, cell phenotype and fate are driven by the mechanical environment. Whereas physiological mechanical stress defines and stabilizes normal cell phenotype, aberrant mechanical signals trigger phenotypic alteration, leading to inflammation and vascular remodelling. Despite recent advances, how mechanical cues impact gene expression to specify cell phenotype remains poorly unders ...
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 1

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ERA NET NEURON in the area of brain-related diseases and disorders of the nervous system (NEURON Cofund)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

The ERA-NET NEURON Cofund will coordinate and align European and international research funding programmes in the area of brain-related diseases and disorders of the nervous system. Key activity is the implementation of an EC co-funded joint transnational call for research proposals. The mission of NEURON is based on the fact that disorders of the brain are the major cause for impaired quality of ...
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 22

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Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease (Foie Gras)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of ...
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 11

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Liaison in Scientific Training for European auditory Neuroscience (LISTEN)

Start date: Dec 1, 2016, End date: Nov 30, 2020,

...must acquire a broad and detailed background in neuroscience, acoustics, biophysics and signal processing, and employ genetic, molecular, pharmacology, anatomy and imaging methods. No single European institute can encompass this, but together, our LISTEN network will enable young scientists and entrepreneurs to unravel hearing mechanisms and design the next-generation of treatments. Work Package 1 ...
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 9

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Ependymal cell Development: New insight into neurological diseases (EDeN)

Start date: Dec 1, 2015, End date: Nov 30, 2020,

Understanding how billions of neurons are born, migrate and integrate into functional circuits has proved useful in elucidating the pathomechanisms of many neurodevelopmental disorders. Multiciliated ependymal cells have attracted less interest and their development is still enigmatic. However, their strategic location at the interface between brain ventricles and parenchyma and their unique morph ...
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 1

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Training, Research and Raising of Public Awareness in Cell Biology and Pathology of Neuroglia (EU-GliaPhD)

Start date: Dec 1, 2016, End date: Nov 30, 2020,

The research in which the young scientists of the EU-GliaPhD consortium will be trained is centred on the role of neuron-glia interactions in brain function and pathology.Prompted by exciting discoveries of recent years, many academic research groups are currently focussing their research on the field of neuron-glia interactions for a better understanding of brain function. Also the private sector ...
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 13

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European AIDS Vaccine Initiative 2020 (EAVI2020)

Start date: Nov 1, 2015, End date: Oct 31, 2020,

...ogens and vaccine modalities with reduced risk of failure in late stage development. To overcome this bottleneck some of the most competitive research groups in vaccine discovery from European public institutions and biotechs from 9 EU countries together with top Australian and Canadian groups and US collaborators, have agreed to join forces in EAVI, providing a pool of international expertise at ...
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Brain-behavior forecasting: The causal determinants of spontaneous self-initiated action in the study of volition and the development of asynchronous brain-computer interfaces. (ACTINIT)

Start date: Oct 1, 2015, End date: Sep 30, 2020,

"How are actions initiated by the human brain when there is no external sensory cue or other immediate imperative? How do subtle ongoing interactions within the brain and between the brain, body, and sensory context influence the spontaneous initiation of action? How should we approach the problem of trying to identify the neural events that cause spontaneous voluntary action? Much is understood a ...
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 1

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Neural regulation of immunity (NEURIMMUNE)

Start date: Oct 1, 2015, End date: Sep 30, 2020,

Survival of living organisms depends on their capacity to develop defence mechanisms against environmental challenges that cause tissue damage and infections. These protective functions involve the nervous system and the immune system, two systems traditionally considered as independent. However anatomical and cellular bases for bidirectional interactions between them have been established and a n ...
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 1

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A developmental engram for the organization of adult hippocampal circuits (NeuroPioneers)

Start date: Oct 1, 2015, End date: Sep 30, 2020,

Most adult cortical dynamics are dominated by a minority of highly active neurons distributed within a silent neuronal mass. If cortical spikes are sparse, spiking of single distinct neurons can impact on network dynamics and drive an animal’s behavior. It is thus essential to understand whether this active and powerful minority is predetermined and if true to uncover the rules by which it is set ...
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 1

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Structure and Dynamics of Low-Complexity Regions in Proteins: The Huntingtin Case (chemREPEAT)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Proteins hosting regions highly enriched in one or few amino acids, the so-called Low-Complexity Regions (LCR), are very common in eukaryotes and play crucial roles in biology. Homorepeats, a subfamily of LCR that present stretches of the same amino acid, perform very specialized functions facilitated by the localized enrichment of the same physicochemical property. In contrast, numerous severe pa ...
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 1

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Unraveling Principles of PDZ-mediated Cell Signaling (PDZnet)

Start date: Sep 1, 2016, End date: Aug 31, 2020,

...tific and transferable skills, the students will receive an interdisciplinary, intersectoral and innovative doctoral training from experienced industrial and academic leaders in well-reputed European Institutions.
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REgenerative Stem cell therapy for STroke in Europe (RESSTORE)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families. Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke ...
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A mimetic implant for low perturbation, stable stimulation and recording of neural units inside the brain. (BRAIN MICRO SNOOPER)

Start date: Aug 1, 2015, End date: Jul 31, 2020,

Developing brain implants is crucial to better decipher the neuronal information and intervene in a very thin way on neural networks using microstimulations. This project aims to address two major challenges: to achieve the realization of a highly mechanically stable implant, allowing long term connection between neurons and microelectrodes and to provide neural implants with a high temporal and s ...
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 1

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iABC Programme (IABC PROGRAMME)

Start date: Aug 1, 2015, End date: Jul 31, 2020,

Cystic Fibrosis (CF) is a common fatal inherited disease with a frequency of 1 in 2500 live births, affecting approximately 36,000 (0.737/10,000) people in the EU. Chronic bacterial pulmonary infection leading to an irreversible decline in lung structure and function is the main cause of mortality and morbidity in patients with CF, with more than 95% of deaths due to respiratory failure. Pseudomon ...
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