4 European Projects Found
Searched on 125080 European Projects
FINISHED
An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)
Start date: Jan 1, 2016, End date: Dec 31, 2021,
The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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43
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FINISHED
Production and characterization of endocrine cells derived from human pancreas organoids for the cell-based therapy of type 1 diabetes (LSFM4LIFE)
Start date: Jan 1, 2016, End date: Dec 31, 2019,
Self-renew and multilineage potential characterize stem cells. We have recently described that pancreas progenitor cells extracted from adult donors can be expanded long-term in vitro into 3D structures, which we have termed organoids. Pancreas organoids reproduce in vitro all the features of pancreas ductal epithelia, and have a limitless expansion potential. Thus, pancreas organoids promise t ...
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7
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FINISHED
Hepatic and Cardiac Toxicity Systems modelling (HECATOS)
Start date: Oct 1, 2013, End date: Sep 30, 2018,
HeCaToS aims at developing integrative in silico tools for predicting human liver and heart toxicity. The objective is to develop an integrated modeling framework, by combining advances in computational chemistry and systems toxicology, for modelling toxic perturbations in liver and heart across multiple scales. This framework will include vertical integrations of representations from drug(metabol ...
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14
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FINISHED
The Body-on-a-Chip (BoC) (BOC)
Start date: Jun 1, 2012, End date: May 31, 2015,
High attrition and failures rates in pharmaceutical and biotechnological drug development require a paradigm change towards more physiological human cell-based assays at an early time point in the process. The central idea of this proposal is to develop a versatile and reconfigurable pharmaceutical screening technology platform that relies on organotypic three-dimensional spherical microtissues. T ...
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