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"The overriding goal of this project is to mimic Nature in the design of novel nucleic acid/peptide chimera based nanodevices that can enable cancer imaging. We will design, engineer and optimize highly specific biomolecular nanodevices that undergo binding-induced conformational changes upon target binding and, in doing so, signal the presence of the cancer marker. This scientific goal of great ...
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The overriding goal of the proposed research program is the development of novel reagentless, electrochemical peptide based sensors for the detection of multiple diagnostic proteins. The approach, which will utilize electrochemistry to monitor the binding-induced folding of peptide/polypeptide used as recognition elements, will be rapid, specific, convenient, and critically, selective enough to b ...
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