Search for European Projects

25 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Comparing the effectiveness of palliative care for elderly people in long term care facilities in Europe (PACE)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"Aging populations, rising costs and sustainable delivery of high-quality care are increasingly common concerns in all EU countries. PACE aims to perform comparative effectiveness research concerning palliative care in long term care facilities (LTCFs) in Europe. While a growing number of older people will require palliative care in institutionalized settings, palliative care has only recently beg ...
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 13

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Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy (DESIRE)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

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Biomarker Research Alliance for Diagnosing Heart Disease in the Ageing European Population (BESTAGEING)

Start date: Feb 1, 2013, End date: Jan 31, 2018,

The ageing of the European population represents a rapidly rising social and economic challenge. Especially cardiovascular morbidity increases with age, but unfortunately, elderly patients are often difficult to diagnose due to confounding factors, leading to uncertainties in clinical decision making with huge impact on patients’ outcomes. Hence, there is an unmet need for novel biomarkers for mor ...
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 22

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Preserving old antibiotics for the future : assessment of clinical efficacy by a pharmacokinetic/pharmacodynamic approach to optimize effectiveness and reduce resistance for off-patent antibiotics (AIDA)

Start date: Dec 1, 2011, End date: Nov 30, 2017,

The AIDA project aims to answer the question of clinical effectiveness and optimal dosing of 5 off-patent antibiotics for infections caused by multiple drug resistant (MDR) bacteria in three randomized controlled clinical trials. In an era of increasing emergence of drug resistance (EDR) and lack of new antibiotics, old off- patent antibiotics are increasingly being prescribed to patients. However ...
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 19

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The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on all-cause mortality in acute myocardial infarction (BAMI)

Start date: Nov 1, 2011, End date: Oct 31, 2017,

Although the long term prognosis of patients suffering acute myocardial infarction (AMI) has improved since the introduction of reperfusion therapies and primary angioplasty, the 1 year mortality of patients with AMI and resultant left ventricular systolic dysfunction (LVSD) is still as high as 13%. A major reason for the high morbidity and mortality is that the heart has an inadequate regenerativ ...
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 23

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NEurocontrolled BIdirectional Artificial upper limb and hand prosthesiS (NEBIAS)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

The NEBIAS ("NEurocontrolled BIdirectional Artificial upper limb and hand prosthesiS") proposal aims at developing and clinically evaluating (in selected amputees) a neuro-controlled upper limb prosthesis intuitively controlled and felt by the amputee as the natural one. This will be possible by means of a novel neural interface able to provide a stable and very selective connection with the nervo ...
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 6

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Natural sensory feedback for phantom limb pain modulation and therapy (EPIONE)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

"Amputation of a limb may result from trauma or surgical intervention. The amputation traumatically alters the body image, but often leaves sensations that refer to the missing body part. In 50-80% amputees, neuropathic pain develops, also called phantom limb pain (PLP). Both peripheral and central nervous system factors have been implicated as determinants of PLP. Also, PLP may be triggered by ph ...
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 13

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A RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTI-MODAL INTERVENTION IN OLDER PEOPLE WITH TYPE 2 DIABETES ON FRAILTY AND QUALITY OF LIFE: THE MID-FRAIL STUDY (MID-FRAIL-STUDY)

Start date: Mar 1, 2012, End date: Apr 30, 2017,

The prevalence of diabetes in people ≥ 65 years approaches 25% (40% of all patients with diabetes are > 65 years). This number will increase 4-fold in people > 70 years in 2050. Diabetes results in a high personal and social health burden, and a significant public health burden in terms of rising healthcare costs. Diabetes is associated with increased functional decline in older people and may exp ...
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 17

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BIOIMAGE-Neuromuscular Diseases (BIOIMAGE-NMD)

Start date: Oct 1, 2013, End date: Mar 31, 2017,

BIOIMAGE-NMD will develop and apply imaging technology to monitor response to novel therapies in neuromuscular diseases (NMD) and will use Duchenne muscular dystrophy (DMD) as an exemplar disease. DMD is well characterised genetically and clinically but to date a disease modifying treatment is not available. One of the most promising developments for future treatment of NMD is RNA modulation throu ...
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 9

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End-user driven DEmo for cbrNe (EDEN)

Start date: Sep 1, 2013, End date: Dec 31, 2016,

The accidental or deliberate release of CBRNE materials are low probability events that can have a significant impact on citizens and society. Whenever and wherever they occur, they usually require a gradual and multi-facetted response as they tend to provoke severe and unexpected physical, psychological, societal, economical and political effects that cross EU-borders. Successful CBRNE resilience ...
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 47

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Identifying best practices for care-dependent elderly by Benchmarking Costs and outcomes of community care (IBENC)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

Problem:The need for cost effective health systems in Europe is imperative in the context of an increasing demand for health care by growing numbers of elderly people and a shrinking working force. Many health care systems are changing and looking for mechanisms to ensure, measure and improve the quality of care. On the other hand it is unclear which models of care delivery are the most cost-effec ...
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 8

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Platform for European Medical Support during major emergencies (PULSE)

Start date: May 1, 2014, End date: Oct 31, 2016,

In Europe, one of the core emergency response services to deadly threats such as pandemic disease and major terrorism attacks is the European Health Services (EHS). The EHS comprise key stakeholders that include hospitals, community health services, pre-hospital emergency care services, medical suppliers, rescue services, health related voluntary services and others. It is crucial to the EHS that ...
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 9

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A phase I/IIa clinical trial in Duchenne muscular dystrophy using systemically delivered morpholino antisense oligomer to skip exon 53 (SKIP-NMD)

Start date: Nov 1, 2012, End date: Apr 30, 2016,

Duchenne muscular dystrophy (DMD) is a progressive, lethal muscle degenerative condition arising from the absence of dystrophin in skeletal and cardiac muscles. 65% of DMD boys have out-of-frame deletions. Modulation of pre-mRNA splicing by exon skipping is the most promising molecular intervention in DMD. 2 Phase Ib and 2 Phase IIa clinical trials (MDEX Consortium in collaboration with Sarepta Th ...
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 10

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Biomarker for Cardiovascular Risk Assessment in Europe (BiomarCaRE)

Start date: Oct 1, 2011, End date: Mar 31, 2016,

Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role in the drive towards personalised medicine remains uncertain.Based on harmonised and standardised European population cohorts we have built significant research collabo ...
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 31

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EUROPEAN NETWORK for CANCER research in CHILDREN and ADOLESCENTS (ENCCA)

Start date: Jan 1, 2011, End date: Dec 31, 2015,

"ENCCA aims to establish a durable, European Virtual Institute clinical and translational research in childhood and adolescent cancers that will define and implement an integrated research strategy and will facilitate the necessary investigator-driven clinical trials to introduce the new generation of biologically targeted drugs into standard of care for children and adolescents with cancer. This ...
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 34

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Optimisation of treatment with off-patent antimicrobial agents of ventilator-associated pneumonia (VAP) (MagicBullet)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

Background. Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, and “old” dru ...
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 11

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Prediction of cognitive properties of new drug candidates for neurodegenerative diseases in the early clinical development (PHARMA-COG)

Start date: Jan 1, 2010, End date: Dec 31, 2015,

PHARMA-COG aims to develop a new integrated model to accelerate the development of drug cindidates for MS, PKD and AD. The innovation relies on a 'multidimensional matrix' approach, integrating all available and renewed inputs (biomarkers/animal, human models/physiological and pharmcological challenges, Phase 0/1/1b to reduce the attrition rate, to allow an early and pertinent GO/NOGO decision bef ...
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 38

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Integrated health technology assessment for evaluating complex technologies (INTEGRATE-HTA)

Start date: Jan 1, 2013, End date: Dec 31, 2015,

"The rise of complex, chronic diseases in an ageing European population led to the development of increasingly complex technologies. Current HTA is not well equipped to assess complex technologies due to a lack of attention to the diversity in patient characteristics and patient preferences, the limited consideration of context and implementation issues, and missing strategies to integrate all the ...
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 7

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Adopting Hospital Based Health Technology Assessment in EU (AdHopHTA)

Start date: Sep 1, 2012, End date: Nov 30, 2015,

The use of HTA as a part of the decision-making process at national, regional, and international levels has evolved considerably over the past 35 years. However, still an important number of good-value innovative HTs never reach clinical practice while, in many instances, others with no significant added value actually do. This situation can be effectively overcome by approaching HTA at hospital l ...
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 11

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SUrrogate markers for vascular Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT)

Start date: Nov 1, 2009, End date: Oct 31, 2015,

Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Worldwide prevalence figures estimate that there will be 246 million diabetic patients in 2007 and 380 million in 2025. Presently, diabetes can neither be prevented nor cured and the disease is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular disease) as we ...
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 27

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Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED)

Start date: Oct 1, 2009, End date: Sep 30, 2015,

RationaleThe inability of pre-clinical studies to predict clinical efficacy is a major bottleneck in drug development. In severe asthma this bottleneck results from: a lack of useful and validated biomarkers, underperforming pre-clinical models, inadequate and incomplete sub-phenotyping, and insufficient disease understanding.HypothesisThe use of biomarker profiles comprised of various types of hi ...
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 42

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Coordination Action for the early implementation of the Joint Programming Initiative (JPI) 'More Years – Better Lives – the Challenges and Opportunities of Demographic Change' (J-AGE)

Start date: Sep 1, 2012, End date: Feb 28, 2015,

J-AGE, the Coordination Action for the early implementation of the Joint Programming Initiative (JPI) 'More Years – Better Lives – the Challenges and Opportunities of Demographic Change', will support and foster the overall management of the JPI, the development of the Strategic Research Agenda and its implementation through joint activities between Member States, the mapping of relevant national ...
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 11

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Impact of Specific Antibiotic Therapies on the prevalence of hUman host ResistaNt bacteria (SATURN)

Start date: Jan 1, 2010, End date: Dec 31, 2014,

"Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of antimicrobial resistance (AMR) have lacked a holistic view combining all aspects into one study. The SATURN project aims to study the impact of antibiotic exposure on AMR with a multidisciplinary approach that bridges molecular, epidemiological, clinical and pharmacological research. Two ...
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 16

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Services and Health for Elderly in Long TERm care (SHELTER)

Start date: Jan 1, 2009, End date: Dec 31, 2011,

"One of the most relevant obstacle to assess and compare nursing home (NH) services and patients across countries relates to the fact that standardized and validated methodologies are not routinely in use in daily practice in Europe. The Minimum Data Set (MDS) is a comprehensive assessment instrument which contains a standardized set of essential clinical and functional status measures and allows ...
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 8

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Novel secretion systems of Mycobacterium tuberculosis and their role in host-pathogen interaction (NOVSEC-TB)

Start date: Jan 1, 2008, End date: Jun 30, 2011,

"Tuberculosis is a major public health threat to the populations of Europe and the world. Mycobacterium tuberculosis, the etiological agent of the disease, can multiply and persist within phagocytic cells and this early event is of primary importance for the outcome of the infection. The main objectives of this proposal are to use highly innovative approaches in molecular and cell biology, biochem ...
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 8