Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Finding noncoding cancer drivers (NONCODRIVERS)

Start date: Dec 1, 2016, End date: Nov 30, 2021,

Finding the mutations, genes and pathways directly involved in cancer is of paramount importance to understand the mechanisms of tumour development and devise therapeutic strategies to overcome the disease. Due to their role in cancer development and maintenance, the proteins encoded by cancer genes are candidate therapeutic targets. Indeed, in recent years we have witnessed the development of suc ...
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European Academy for Biomedical Science (ENABLE)

Start date: Jul 1, 2016, End date: Dec 31, 2020,

The proposed European Academy for Biomedical Science (ENABLE) consortium will connect aspiring European researchers of tomorrow with prominent scientists of today, in particular to inspire and to give them the necessary tools to follow in their footsteps. ENABLE will organize peer-reviewed symposia celebrating European life science achievements from molecule to man/patient. These symposia will hav ...
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 6

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Description of information transfer across macromolecules by concerted conformational changes (CONCERT)

Start date: Jul 1, 2015, End date: Jun 30, 2020,

Signal transduction in biology relies on the transfer of information across biomolecules by concerted conformational changes that cannot currently be characterized experimentally at high resolution. In CONCERT we will develop a method based on the use of nuclear magnetic resonance spectroscopy in solution that will provide very detailed descriptions of such changes by using the information about s ...
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 2

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Dissecting gamma-TuRC composition and activity by Single Molecule Pull-down (GTR)

Start date: Sep 1, 2017, End date: Aug 31, 2019,

In this project I will use Single Molecule Pull-down (SiMPull) for studying activity and regulation of human gamma-tubulin ring complexes (gamma-TuRCs). Gamma-TuRCs are the main nucleators of microtubule (MT) polymerization. Additionally, gamma-TuRCs may play a role in modulating MT dynamics. Regulation of gamma-TuRC activity is key to organizing the dynamic MT arrays needed for essential processe ...
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 2

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ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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A systems pharmacology approach to the discovery of novel therapeutics in Alzheimer´s disease (SysPharmAD)

Start date: Apr 1, 2014, End date: Mar 31, 2019,

Alzheimer´s disease (AD) is the most common form of dementia, with over 35 million people suffering from it worldwide, and it constitutes a personal and societal tragedy of immense proportions. Fifty years of intense research have revealed many key elements of the biology of this neurodegenerative disorder. However, our understanding of the molecular bases of the disease is still very limited, and ...
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A genome editing-based approach to study the stem cell hierarchy of human colorectal cancers (editCRC)

Start date: Apr 1, 2014, End date: Mar 31, 2019,

A hallmark of cancer is tumor cell heterogeneity, which results from combinations of multiple genetic and epigenetic alterations within an individual tumor. In contrast, we have recently discovered that most human colorectal cancers (CRCs) are composed of mixtures of phenotypically distinct tumor cells organized into a stem cell hierarchy that displays a striking resemblance to the healthy colonic ...
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Global BioImaging Project - International imaging infrastructure services for the life science community (Global BioImaging)

Start date: Dec 1, 2015, End date: Nov 30, 2018,

"The EC H2020 funded "Global BioImaging Project" enables Euro-BioImaging, the research infrastructure for access to biological and medical imaging technologies on the ESFRI roadmap, to work together with its international counterparts - the Australian Microscopy and Microanalysis Research Facility (AMMRF), the National Imaging Facility (Australia) and India-BioImaging - on concrete and sustainable ...
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 8

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Multi-Scale Complex Genomics (MuG)

Start date: Nov 1, 2015, End date: Oct 31, 2018,

Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part ...
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 7

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Centre of Excellence for Biomolecular Research (BioExcel)

Start date: Nov 1, 2015, End date: Oct 31, 2018,

Life Science research has become increasingly digital, and this development is accelerating rapidly. Biomolecular modelling techniques such as homology modelling, docking, and molecular simulation have advanced tremendously due to world-leading European research, resulting in extreme demands for better computational performance and throughput as these tools are used in applied research and industr ...
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 13

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IRB Barcelona International Postdoctoral Programme 2.0 (IRBPostPro2.0)

Start date: Apr 2, 2013, End date: Apr 1, 2018,

IRB Barcelona is an independent, non-profit research institution engaged in basic and applied biomedical science at the interface between biology, chemistry and medicine, recently nominated a Severo Ochoa Centre of Excellence by the Spanish Ministry of Science and Innovation. One of the main missions of IRB Barcelona is to provide young life scientists with the opportunity to do training and resea ...
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 2

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Early warning signals of ageing in human stem cells and age-related disorders (SYSTEMAGE)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...
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Spatiotemporal regulation of epidermal stem cells by circadian rhythms: impact on homeostasis and aging (STEMCLOCK)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

"Most adult stem cells are compartmentalized in functionally deterministic niches where they self-renew and maintain homeostasis. From there, stem cells are instructed by combinations of signals and spatial tensile forces which they translate into a specific behavior. However how stem cells spatiotemporally coordinate their stem cell potential with niche- and systemic cues is poorly understood. Th ...
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Signal integration and rewiring during tumor development (p38Cancer)

Start date: Jul 1, 2012, End date: Jun 30, 2017,

Cell fate decisions rely on signaling pathways that integrate external signals to coordinate specific intracellular programs. One of these pathways leads to the activation of p38α MAPK, which plays key roles in cell responses to many types of stresses as well as chemotherapeutic agents and oncogenes. Importantly, p38α acts in a cell context-specific and cell type-specific manner to integrate signa ...
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 2

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Modelling Cancer Traits in Drosophila (FliesCan)

Start date: Jul 1, 2012, End date: Jun 30, 2017,

Despite significant advance, cancer treatment remains suboptimal. Anatomical and physiological differences between humans and simple model organisms like Drosophila are many and major, and preclude the modelling of key aspects of the disease as it proceeds in vertebrates. However, malignant tumors in vertebrates and flies are made of cells that have derailed from their normal course of development ...
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Advanced multiscale simulation of DNA (simDNA)

Start date: Jul 1, 2012, End date: Jun 30, 2017,

The availability of new computers and software is making possible the theoretical representation of DNA, increasing then our knowledge on the behavior of one of the most relevant biological macromolecules. Unfortunately, current simulation procedures present two major problems, which handicapped their use: i) classical force-fields present well known biases, which limit their accuracy; ii) current ...
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New breast cancer therapies based on available p38 MAPK inhibitors (p38Cure)

Start date: Oct 1, 2015, End date: Mar 31, 2017,

Breast tumors are classified by several grading systems and divided into four main molecular subtypes: Luminal A, Luminal B, Triple negative/basal-like and HER2+. Since luminal A tumors tend to be ER+, their treatment often includes hormonal therapy. HER2+ tumors can be treated with Trastuzumab, an anti-Her2 receptor antibody. Hormonal therapies or Trastuzumab cannot be used for triple negative tu ...
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Study of cis/trans proline isomerization as a novel regulatory mechanism of protein function (ProProteinRegulation)

Start date: Sep 1, 2012, End date: Aug 31, 2016,

Cellular processes are regulated through wide and complex signaling networks that require a tight spatial and temporal control over protein function. Recently a growing body of evidence has emerged supporting the role of prolyl cis-trans isomerization as a new intrinsic molecular regulatory mechanism with important consequences for protein function. Proline is the only amino acid in proteins that ...
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 2

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Computational Design of Highly Active Biocatalysts of Interest in the Chemical Industry (CompBiocatDesign)

Start date: Mar 1, 2013, End date: Aug 31, 2016,

Developing new enzymes for catalyzing non natural reactions is a grand challenge for obtaining more efficient synthetic strategies for chemical industry as well as building complex molecules under enantioselective control with potential applications in medicine. Given the high specificity of natural enzymes for their substrates, new techniques are necessary for redesigning natural enzymes to perfo ...
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 2

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COLOStage : A new prognosis test for the prediction of metastasis in Colorectal Cancer and Hepatocellular Carcinoma (COLOStage)

Start date: Mar 1, 2015, End date: Aug 31, 2016,

ColoStage is a new prognostic test, based on a novel gene expression signature, able to predict robustly the risk of disease relapse after therapeutic intervention in colorectal cancer (CRC) and potentially in hepatocellular carcinoma (HCC). We have previously demonstrated that CRC recurrence and metastasis strictly depend on high TGF-beta signaling (Calon et al., 2012). ColoStage is a gene expre ...
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 2

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Development of a new methodology for the synthesis of mercapto amino acids for protein synthesis by cysteine-free native chemical ligation (CYSTEINE-FREE NCL)

Start date: Apr 14, 2014, End date: Apr 13, 2016,

Proteins are in the heart of almost every single biological function and therefore are essential tools for drug discovery. Although the use of recombinant DNA techniques has been successfully applied to the synthesis of many proteins, the access to proteins bearing non natural amino acids, naturally obtained through post-translational modifications, remains limited. However, with the invention of ...
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 2

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Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression (DEXLIFE)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

"Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Inve ...
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 12

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IRB Barcelona International Postdoctoral Programme (IRBPostPro)

Start date: Nov 15, 2010, End date: Jul 14, 2015,

IRB Barcelona is an independent, non-profit research institution engaged in basic and applied biomedical science at the interface between biology, chemistry and medicine. One of the main missions of IRB Barcelona is to provide young life scientists with the opportunity to do training and research in a unique and multidisciplinary scientific environment. The Institute has a young but well-establish ...
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 2

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Study of the Determinants of Heterochromatin Formation and Maintenance (HETCHROMPROJECT)

Start date: Jun 1, 2011, End date: May 31, 2015,

Heterochromatin is a conserved organizational structure of the genetic material that is indispensable for cell viability. Heterochromatin is associated with the formation of functionally conserved centromeric and telomeric structures. These structures are both essential for the integrity and proper segregation of the genetic material during mitosis and meiosis. Heterochromatin structure is also im ...
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 2

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Peptide Dendrimers - A Chemical Platform for Functional Diversity (Peptide Dendrimers)

Start date: Jun 13, 2011, End date: Jun 12, 2014,

Peptides have emerged as a therapeutically important class of drugs and offer the advantage of great specificity, potency and low toxicity. Short circulation half-life, poor proteolytic stability and bioavailability have however prevented them from becoming a mainstream source of drug candidates. Dendrimers are versatile, derivatizable, well-defined branched synthetic macromolecules with promising ...
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 2

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"Nuclease Immune Mediated Brain and Lupus-like conditions (NIMBL): natural history, pathophysiology, diagnostic and therapeutic modalities with application to other disorders of autoimmunity" (NIMBL)

Start date: Jun 1, 2010, End date: Nov 30, 2013,

"Nuclease Immune Mediated Brain and Lupus-like (NIMBL) conditions, comprising Aicardi-Goutieres Syndrome, Retinal Vasculopathy with Cerebral Leukodystrophy and some cases of Systemic Lupus Erythematosus, are devastating genetic disorders resulting in greatly reduced quality of life, high mortality especially in children, and significant risks of recurrence within affected families. NIMBL condition ...
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Membrane Enhanced Tide Synthesis - A New Paradigm Peptide / Oligonucleotide Synthesis Technology (MEMTIDE)

Start date: Dec 1, 2009, End date: Nov 30, 2013,

"The MemTide Initial Training Network will create a new generation of synthesis technologies for peptide and oligonucleotide (“tide”) manufacture, with focus on the use of emerging membrane technology to effect critical separations. New nanofiltration membranes with improved chemical stability, and closely controlled molecular discrimination properties, will be developed. Novel synthesis strategie ...
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Ligand Engineering for Pauson-Khand Reactions (LE-PKR)

Start date: Sep 1, 2011, End date: Nov 30, 2013,

"This project is centered on several technological developments around the intermolecular Pauson-Khand reaction, a cobalt catalyzed multicomponent cycloaddition with an unexploited potential to streamline the synthesis of complex organic molecules. The first aim is to find new ligands for the cobalt catalyzed intermolecular Pauson-Khand reaction. A ligand accelerated version of this transformation ...
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 2

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Epigenetic control of chromatin structure - Solving an intertwined puzzle with a specialized coarse-grained model (EPICHROMATIN)

Start date: Sep 15, 2011, End date: Sep 14, 2013,

"This project will develop a highly sophisticated coarse-grained model of chromatin fibers from precise all-atom simulations of dinucleosomes and DNA segments. The purpose of the proposed project is to enhance our understanding of the mechanism by which different patterns of epigenetic modifications (of DNA and histone proteins) interact with each other to control the structure of the chromatin fi ...
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 2

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Scalable Software Services for Life Science (ScalaLife)

Start date: Sep 1, 2010, End date: Aug 31, 2013,

Life Science is developing into one of the largest e- Infrastructure users in Europe, in part due to the ever-growing amount of biological data. Modern drug design typically includes both sequence bioinformatics, in silico virtual screening, and free energy calculations, e.g. of drug binding. This development will accelerate tremendously, and puts high demands on simulation software and support se ...
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Studies of neurosecretion by remote control of exocytosis and endocytosis with ligt (OPTICALBULLET)

Start date: Sep 1, 2008, End date: Aug 31, 2013,

"Optical switches are photoisomerizable compounds that allow to remotely controlling the activity of proteins, cells and entire organisms with light. These tools are revolutionizing research in biology with their high selectivity and spatiotemporal resolution. Here we propose to develop and apply optical switches to investigate the fundamental processes of secretion, exocytosis and endocytosis, in ...
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Dissecting the roles of the beta-catenin and Tcf genetic programmes during colorectal cancer progression (CRC programme)

Start date: Sep 1, 2008, End date: Aug 31, 2013,

Most colorectal cancers (CRCs) are initiated by activating mutations in components of the Wnt signalling pathway. Physiological Wnt signals are required for the specification and maintenance of the stem and progenitor cell compartments of the intestinal crypts. We demonstrated that early colorectal lesions exhibit a constitutive Wnt target gene programme, which is very similar to that of normal in ...
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 2

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Identification and validation of novel drug targets in Gram-negative bacteria by global search: a trans-system approach (AntiPathoGN)

Start date: Feb 1, 2009, End date: Jul 31, 2013,

Multi-drug-resistant bacterial infections are increasing at an alarming pace in both developing and developed countries and in both community and nosocomial settings. The few antimicrobial agents that have been launched during the last decade (e.g. linezolid, daptomycin) have a good activity against Gram-positive bacteria. However, multi-drug-resistant bacteria are often found among the Gram-negat ...
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Incorporating flexibility into protein-ligand docking (IFLPD)

Start date: Nov 1, 2009, End date: Oct 31, 2012,

"One of the major goals of current drug discovery methods is the correct treatment of the flexibility of the receptor (i.e., protein) in small ligand docking. Computer-aided drug discovery through ligand docking-based virtual screening is already a key component in the lengthy and costly process of developing new drugs not only for academy but also for the pharmaceutical industries. In this propos ...
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 2

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Peptide ligands with restricted mobility through a Suzuki reaction: design, synthesis and evaluation (suzuki peptides)

Start date: Oct 1, 2009, End date: Sep 30, 2012,

The aim of this research proposal is the application of the Suzuki-Miyaura reaction to the synthesis of peptidic libraries with restricted mobility. Specifically, we envision the synthesis of a family of cyclic peptides that will contain a biaryl bond, to further restrain their conformation. This biaryl bond will be obtained through a Suzuki-Miyaura set of reactions between two aromatic amino acid ...
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 2

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Microtubule organizing centers and microtubule nucleation in mitosis (MTOC function)

Start date: Jul 21, 2008, End date: Jul 20, 2012,

Centrosomes are multifunctional organelles crucial for a large number of cellular functions including the organization of microtubules. In mitosis centrosomes contribute to assembly, orientation and function of the mitotic spindle, which is important for proper segregation of the chromosomes. Defects in centrosome number and function are strongly associated with the cancer phenotype and centrosome ...
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 2

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Analysis of the pathological implications of the abnormal accumulation of glycogen in specific cell types (MGS and disease)

Start date: Jul 1, 2010, End date: Jul 13, 2012,

Glucose is stored in specialized tissues (mainly liver and muscle) in the form of a branched polymer called glycogen. Glycogen Synthase is the only enzyme able to catalyze this polymerization and its two isoforms (LGS and MGS) are mainly expressed in liver and in muscle, respectively. However, MGS is also expressed in all other tissues, regardless of their limited capacity to produce Glycogen. MGS ...
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EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS (EDICT)

Start date: Feb 1, 2008, End date: Jun 30, 2012,

"The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infra ...
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Targeting Protein Synthesis in the Apicoplast and Cytoplasm of Plasmodium (MEPHITIS)

Start date: Jan 1, 2009, End date: Jun 30, 2012,

"The protein synthesis machinery represents one of the most useful targets for the development of new anti-infectives. Several families of broadly used antibiotics (tetracyclines, macrolides, and novel glycopeptides like vancomycin, among others) exert their function by blocking the protein synthesis machinery. Doxicycline, a tetracycline antibiotic, remains a useful tool for the prevention of pal ...
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 9

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Intestinal stem cells and their role in colorectal cancer progression (CSC program)

Start date: Jun 1, 2010, End date: May 31, 2012,

Constitutive activation of the Wnt pathway is the key step for initiation of colorectal cancer (CRC). Wnt signaling also plays an essential role in the maintenance of intestinal stem cells (ISCs). In addition, acquisition of a constitutive crypt stem/progenitor phenotype represents the first step towards malignancy. The identification of the Wnt target gene Lgr5 as a marker for ISCs and the findin ...
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