6 European Projects Found
Searched on 125080 European Projects
FINISHED
Targeting cardiac fibrosis for heart failure treatment (FIBRO-TARGETS)
Start date: Sep 1, 2013, End date: Aug 31, 2017,
The Fibro-Targets project is a multi-disciplinary 4 years program involving 10 partners ambitioning “the identification, characterisation and validation of in vitro and in vivo models of novel therapeutically relevant targets” for myocardial interstitial fibrosis (MIF) in heart failure. The project is based on the hypothesis that the intervention on novel fibrosis-related targets involved in the p ...
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11
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BeTheCuRE (BTCURE)
Start date: Apr 1, 2011, End date: Mar 31, 2017,
BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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41
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"From Brain Gene Transfer Towards Gene Therapy: Pharmacological Assessment of AAV, CAV and LVV" (BRAINVECTORS)
Start date: Nov 1, 2012, End date: Oct 31, 2016,
"BRAINVECTORS aims devising new gene therapy(GT)-based treatments for Parkinson’s and other neurodegenerative diseases, in substitution of current systemic treatments, by delivering neurotrophic factors (GDNF) into the CNS with new vectors derived from adeno-associated (AAV), canine adenoviruses (CAV) and lentiviruses (LV) with inducible gene expression.Although AAV, CAV and LVV are considered acc ...
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12
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SAFER AND FASTER EVIDENCE-BASED TRANSLATION (SAFE-T)
Start date: Jun 15, 2009, End date: Jun 14, 2015,
The public-private consortium composed of complementary SMEs, academic and clinical centers of excellence and EMEA as partner proposes SAFE-T (Safer And Easter Evidence-based Iranslation) project for the establishment of a biomarker (BM) qualification process and its validation in clinical biomarker studies designed for the translation, performance testing and eventual regulatory qualifIcatIon of ...
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26
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HER Imaging and Molecular Interaction Mapping in Breast Cancer (IMAGINT)
Start date: May 1, 2011, End date: Apr 30, 2015,
The aim is to develop tools for imaging and characterising protein/protein and protein/RNA interactions in cancer using Designed Ankyrin Repeat Proteins (DARPins). DARPins are small, ultrahighly stable, antibody-like proteins that bind specific targets with high affinity in monovalent form and are readily engineered for site-specific chemical modification. The exemplar protein family will be EGFR, ...
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11
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Treatment of reperfusion injury using a mitochondrial targeted approach: towards a better understanding of the disease (MITOCARE)
Start date: Jan 1, 2011, End date: Dec 31, 2013,
"Current interventional treatment of acute myocardial infarction (AMI) focused on re-establishing cardiac reperfusion has significantly improved clinical outcome by reducing infarct size and mortality due to cardiac ischemia.It is now recognized that events triggered at reperfusion also result in cell death and may account for as much as 50% of the infarct volume, this being termed ischemia-reperf ...
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