7 European Projects Found
Searched on 125080 European Projects
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ONCOLYTIC HERPESVIRUSES RETARGETED TO CANCER- SPECIFIC RECEPTORS (ONCOLYTIC-HERPES)
Start date: Mar 1, 2014, End date: Feb 28, 2019,
Cancer remains a major health burden worldwide. The aggressive targeting of metabolic pathways shared by normal and cancer cells results in prolonged survival and cures, but at a tremendous cost to patient life quality. What is missing is a therapeutic agent that clearly differentiates normal and cancer cells. This proposal delineates a process for killing exclusively cancer cells with no interfer ...
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3
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Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer (CAM-PAC)
Start date: Nov 1, 2013, End date: Oct 31, 2018,
Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di ...
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18
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Targeting Src-family tyrosine kinases in chronic autoimmune and inflammatory diseases (TARKINAID)
Start date: Jan 1, 2012, End date: Dec 31, 2015,
The project aims to develop novel inhibitors of chronic autoimmune and inflammatory diseases by targeting members of the Src tyrosine kinase family. Src-family kinases have recently emerged as major therapeutic targets in malignant diseases but their suitability as potential targets of inflammatory diseases has not yet recieved widespread acceptance. On the other hand, members of the applicant con ...
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11
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Molecular mechanisms controlling leukocyte trafficking in the central nervous system (NEUROTRAFFICKING)
Start date: Oct 1, 2010, End date: Sep 30, 2014,
Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) represent the prototype of autoimmune chronic inflammatory diseases of the central nervous system (CNS). Migration of activated T cells across the blood-brain barrier represents a critical step in the pathogenesis of MS and EAE, and inhibition of lymphocyte trafficking in the CNS represents a powerful ther ...
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2
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Targeting the tumour microenvironment to improve pancreatic cancer prognosis (EPC-TM-Net)
Start date: Feb 1, 2011, End date: Jul 31, 2014,
Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased ...
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17
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Resolve Chronic Inflammation and Achieve Healthy Aging by Understanding Non-regenerative Repair (RESOLVE)
Start date: Apr 1, 2008, End date: Sep 30, 2013,
"RESOLVE has been outlined to better understand the regulatory networks that control the devel-opmental processes in organ repair and to identify mechanisms which cause the termination of regu-lar organ development leading to fibroproliferative wound healing. Fibroproliferative wound healing represents a major pathology in elderly people shifting regular organ development into progressive organ fi ...
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14
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Exploring the Molecular Bases that Regulate Apoptosis, Cytokine production and Interaction with Neutrophil Granulocytes by 6-sulfo LacNAc+ dendritic cells (slanDC) (EMBRACING slanDC)
Start date: Jun 1, 2011, End date: May 31, 2013,
Dendritic cells (DC) are composed of multiple subsets with distinct functions at the interface of the innate and adaptive immunity. Two major subsets of DC circulate in human peripheral blood: the myeloid DC (mDC) and the plasmacytoid DC (pDC), which can be distinguished by the expression of specific surface markers. Within mDC, slanDC are the most abundant in human blood and are characterized by ...
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