6 European Projects Found
Searched on 125080 European Projects
FINISHED
Mechanisms of homeostatic plasticity in the intact mouse visual cortex (HOMEOSTASIS_IN_VIVO)
Start date: Jan 1, 2013, End date: Dec 31, 2018,
Changes in input lead to changes of synaptic circuits in the brain via a combination of synapse specific Hebbian plasticity and cell-wide homeostatic plasticity. While Hebbian plasticity has been well studied, there are still a number of outstanding fundamental questions related to homeostatic plasticity. We have previously developed a paradigm that allows us to monitor changes to multiple homeost ...
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2
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Understanding Mechanisms of Human Social Interaction using Interactive Avatars (INTERACT)
Start date: Jan 1, 2013, End date: Dec 31, 2018,
Human social interaction depends on non-verbal unconscious behaviour as much as on verbal signals. Mimicry (unconscious copying of actions) is a good example of a social behaviour which is caused by and has consequences for our evaluation of others. However, studying mimicry with traditional methods is hard because of the trade-off between good experimental control and realistic social interacti ...
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2
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Cultured Liver Organoids for Investigation and Treatment of Inherited Cholestatic Diseases (CLOC)
Start date: Jan 1, 2014, End date: Dec 31, 2018,
"Bile synthesis and secretion are crucial to liver function and involve multiple proteins. Disorders due to defects in this process (Inherited Cholestatic Disorders, ICDs) lead to progressive liver disease. Many ICD patients do not respond to medical treatment and need liver transplantation (LT). Although ICDs are rare, multifactorial cholestatic diseases are common and many patients will benefit ...
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1
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Autophagy as a cancer treatment (CANCERPHAGY)
Start date: Oct 1, 2012, End date: Sep 30, 2018,
Cancer is one of the most prevalent human killer diseases. Autophagy, a lysosome-mediated process that degrades cellular components and damaged organelles, has recently emerged as an important player in cancer. Indeed, autophagy inhibition promotes cancer initiation through generation of genomic instability and inflammation, whereas in contrast, autophagy activation is often required to sustain gr ...
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1
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Activity-Dependent Maturation of Inhibitory Processing in the Spinal Dorsal Horn (ADMIP)
Start date: Mar 1, 2015, End date: Feb 28, 2018,
In the early postnatal period neonates are particularly sensitive to touch, often responding with exaggerated reflexes and whole-body movements to an isolated cutaneous stimulus. This suggests a predominance of excitation over inhibition in spinal sensory networks, which may facilitate activity-dependent synaptic strengthening. We have recently shown that neonatal hypersensitivity to touch is due ...
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The development of the hippocampal spatial representation system (DEVSPACE)
Start date: Jan 1, 2012, End date: Dec 31, 2017,
This proposal will address how a multimodal cognitive system, the neural representation of space in the hippocampus, emerges during development. There is a long tradition in neuroscience of studying the development of primary sensory systems, but fewer studies have concentrated on the development of brain networks supporting higher-order cognitive representations.Our recent findings (Wills, Cacucc ...
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