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Chemical biology approach to study the role of PDZ domain-mediated interactions in synaptic plasticity (neuroCHEMbiotools)

Start date: May 1, 2011, End date: Apr 30, 2013,

Complex dynamic protein-protein interactions are the base of protein-based networks in cells. Among them, the synaptic connection between two neurons is one of the most challenging. The postsynaptic density (PSD) at excitatory synapses in the brain is a prototypical example of protein-based network whose nanoscale structure and composition determines cellular function. Moreover, dynamic regulation ...
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 FINISHED 

Role of lateral diffusion of AMPA Receptors in LTP (TRAPAMPAR)

Start date: Mar 1, 2010, End date: Feb 29, 2012,

Synaptic recruitment of AMPA receptors (AMPAR) is a critical step in synaptic plasticity events such as Long term potentiation (LTP). Although the signaling events necessary for the induction of LTP are well known (i.e. NMDA receptor activation and activation of protein kinase cascades), the source of the newly inserted AMPAR is still unclear. There are two pools of AMPA receptors that can be pote ...
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