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Structural analysis of the CSA binding interactions involved during pregnancy associated malaria (PreMalStruct)
Start date: Feb 1, 2008, End date: Jul 31, 2011,
Adhesion of Plasmodium falciparum-infected erythrocytes (PE) to placental chondroitin-4-sulfate (CSA) has been linked to the severe disease outcome of pregnancy-associated malaria (PAM). After multiple pregnancies, women acquire protective antibodies that block CSA-binding and cross-react with geographically diverse placental isolates suggesting that surface molecule(s) expressed by PAM-infected e ...
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