4 European Projects Found
Searched on 125080 European Projects
FINISHED
Early Prevention of Diabetes Complications in people with Hyperglycaemia in Europe (E-PREDICE)
Start date: Jan 1, 2012, End date: Dec 31, 2017,
"Background: A significant proportion of pre-diabetics, show macro and micro vascular complications associated with hyperglycaemia. Although many trials have demonstrated the efficacy of lifestyle and pharmaceutical interventions in diabetes prevention, no trial has evaluated the extent to which mid- and long-term complications can be prevented by early interventions on hyperglycaemia.Aims: To ass ...
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37
Partners Participants
FINISHED
Safety Evaluation of Adverse Reactions in Diabetes (SAFEGUARD)
Start date: Oct 1, 2011, End date: Sep 30, 2015,
"In 2010 a widely marketed drug for the treatment of type 2 diabetes (T2DM) (rosiglitazone) was taken from the market as it was associated with an increased risk of myocardial infarction, a T2DM complication it was actually supposed to prevent. This example shows several things. First, the approval requirements do not guarantee a longer term positive benefit risk profile. Second, large scale postm ...
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19
Partners Participants
FINISHED
Tissue Transmigration Training Network (T3Net)
Start date: Sep 1, 2009, End date: Aug 31, 2013,
Cardiovascular and cancer-related diseases are the leading causes of human mortality and disability. The underlying mechanisms originate from chronic interstitial cell activation leading to pathological tissue remodelling and malfunction of cells. These depend on three fundamental processes: cell adhesion, migration, and modulation/degradation of the extracellular matrix (ECM), which together dete ...
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8
Partners Participants
FINISHED
"Pathophysiology of rare diseases due to ciliary dysfunction: nephronophthisis, Oral-facial-digital type 1 and Bardet-Biedl syndromes" (EUCILIA)
Start date: Feb 1, 2008, End date: Jan 31, 2011,
"Primary cilia have been recognized on nearly all-mammalian cells. Emerging data suggest that they act as cellular antennae with diverse motility and sensory functions, detecting a wide variety of signals. As such, defects in cilia formation or function have profound effects on the development of body pattern and the physiology of multiple organ systems. Ciliary defects underlie a wide range of hu ...
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