3 European Projects Found
Searched on 125080 European Projects
FINISHED
Smart multifunctional GLA-nanoformulation for Fabry disease (Smart-4-Fabry)
Start date: Jan 1, 2017, End date: Dec 31, 2020,
Lysosomal storage disorders (LSD) diseases are a group of rare diseases that currently lack a definitive cure. LSD incidence is about 1:5,000 - 1:10,000, representing a serious global health problem. In the case of Fabry LSD Disease (FD), the deficiency in α-Galactosidase A (GLA) enzyme activity results in the cellular accumulation of neutral glycosphingolipids, leading to widespread vasculopathy ...
Read Project
10
Partners Participants
FINISHED
Stem Cells for Relevant Efficient Extended and Normalized Toxicology (SCR&TOX)
Start date: Jan 1, 2011, End date: Dec 31, 2015,
In the development of products for use by humans it is vital to identify compounds with toxic properties at an early stage of their development, to avoid spending time and resource on unsuitable and potentially unsafe candidate products. Human pluripotent stem cell lines offer a unique opportunity to develop a wide variety of human cell-based test systems because they may be expanded indefinitely ...
Read Project
16
Partners Participants
FINISHED
EUROpean consortium for antiCALINs as next generation high-affinity protein therapeutics (EUROCALIN)
Start date: Aug 1, 2011, End date: Nov 30, 2015,
The consortium aims to develop and produce an Anticalin, a member of a novel high-affinity scaffold derived from the lipocalin protein family. The Anticalin is specific for hepcidin which is a central regulator of iron homeostasis, and will be used to antagonize hepcidin for the treatment of “anemia of chronic disease” (ACD). Anticalins are genetically modified lipocalins that can target almost an ...
Read Project
