Search for European Projects

7 European Projects Found

Searched on 125080 European Projects

 FINISHED 

FRAGments training NETwork (FRAGNET)

Start date: Mar 1, 2016, End date: Feb 29, 2020,

The promise of more efficient lead discovery is fuelling the enthusiasm for fragment-based lead discovery (FBLD). In this approach, highly sensitive biochemical and biophysical screening technologies are being used to detect the low affinity binding of low molecular weight compounds (the so-called fragments) to protein targets that are involved in pathophysiological processes. By investigating the ...
Read Project

 9

 FINISHED 

European Gram Negative Antibacterial Engine (ENABLE)

Start date: Feb 1, 2014, End date: Jan 31, 2020,

The intensive use and misuse of antibiotics has resulted in some level of antibiotic resistance in essentially all human bacterial pathogens. There is a growing concern that the loss of therapeutic options will present us with a post-antibiotic era where present and future medical advances are negated. Resistant bacteria dramatically reduce the possibilities of treating infections effectively, a ...
Read Project

 42

 FINISHED 

Synaptic Systems: dissecting brain function in health and disease (SYNSYS)

Start date: Jul 1, 2010, End date: Dec 31, 2014,

Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
Read Project

 19

 FINISHED 

Development of novel antiviral drugs against Influenza (FLUCURE)

Start date: Oct 1, 2010, End date: Sep 30, 2014,

"Influenza viruses cause a highly contagious respiratory disease in both humans and animals. Typically, influenza spreads worldwide in seasonal epidemics resulting in an estimated 3 to 5 million cases of severe illness and 250,000 to 500,000 deaths annually. In addition to these seasonal epidemics there have been several pandemics since the early 1900’s, where highly virulent strains emerged, the ...
Read Project

 11

 FINISHED 

BrainTrain: Integrative neuroscience school on brain function and disease (BrainTrain)

Start date: Nov 1, 2009, End date: Oct 31, 2013,

Brain disorders, in particular neurodegenerative diseases and mental illnesses are among the most prevalent and debilitating diseases. Because they are chronic, quality of life and socio-economic prospects are dramatically impaired. Increased life expectancy further enhances the impact of brain dysfunction on society. In coming decades this burden will grow into one of most pressing and costly pro ...
Read Project

 14

 FINISHED 

Neurotransmitter Cys-loop receptors: structure, function and disease (NeuroCypres)

Start date: Feb 1, 2008, End date: Jul 31, 2012,

Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disord ...
Read Project

 24

 FINISHED 

Combating influenza using a novel drug strategy (FluDrugStrategy)

Start date: Mar 1, 2008, End date: Aug 31, 2010,

Objective: To find and produce novel target compounds against the influenza virus. Influenza A capsid protein is the target since it does not mutate at the same rate as the Hemagglutinin or Neuraminidase proteins. We aim to develop new therapeutic antiviral solutions to combat the disease. Beyond state of the art: The project combines knowledge based design and synthesis of compounds with unique p ...
Read Project

 5