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Adult stem cells are essential for the lifelong maintenance and regeneration of various organs and tissues. Experimental and clinical data indicate that the functional capacity of adult stem cells in organ regeneration declines during aging. Molecular mechanisms that cause impairments in stem cell function during aging remain to be delineated. Genetic analyses identified a growing number of genes ...

Healthy brain ageing is a major determinant of quality life-long health, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to life style and genetic factors, environmental influences in prenatal life have a major impact on brain ageing and age-associated brain disorders. We hypothesize that: (1) prenatal stress programs early brain ag ...