4 European Projects Found
Searched on 125080 European Projects
FINISHED
NOX enzymes as mediators of inflammation-triggered neurodegeneration: modulating NOX enzymes as novel therapies (NEURINOX)
Start date: Jan 1, 2012, End date: Dec 31, 2016,
NEURINOX aims at elucidating the role of NADPH oxidases (NOX) in neuroinflammation and its progression to neurodegenerative diseases (ND), as well as evaluating the potential of novel ND therapeutics approaches targeting NOX activity. NOX generate reactive oxygen species (ROS) and have emerged as regulators of neuroinflammation. Their role is complex: ROS generated by NOX lead to tissue damage in ...
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15
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The prion protein in health and disease (PRIONS)
Start date: May 1, 2010, End date: Apr 30, 2015,
Oligomers are toxic in an array of protein misfolding and aggregation (PMA) disorders. However, the chain of events from protein aggregation to dysfunction is poorly understood. Prion diseases are marked by accumulation of PrPSc, a misfolded variant of wild-type PrPC. PrPC mediates PrPSc neurotoxicity and counteracts toxic PrPC mutants, indicating that a subversion of normal PrPC function may unde ...
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1
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Protecting the food chain from prions: shaping European priorities through basic and applied research (PRIORITY)
Start date: Oct 1, 2009, End date: Sep 30, 2014,
"Bovine Spongiform Encephalopathy (BSE) started, 20 years ago, a devastating health and food crisis throughout Europe. Classical BSE is now under control as a result of the meat and bone meal ban. However, tonsil analyses suggest that there may be an alarmingly high number of asymptomatic PrPSc positive cases. Transmission through blood transfusion is another important concern, as are recent “atyp ...
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21
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Luminescent polymers for in vivo imaging of amyloid signatures (LUPAS)
Start date: Nov 1, 2009, End date: Dec 31, 2012,
"In this project we seek to develop new smart imaging molecular tools for combating neurodegenerative diseases such as Alzheimer’s disease and prion diseases. Emphasis is put on translational applied research for the development and validation of novel properly functionalized luminescent conjugated polymers (LCP) that via modern imaging technology can give rise to entirely new and innovative metho ...
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