In the past years the Pannonian plain has been attacked by Ambrosia Artemisiifolia. This plant, next to its allergenic properties, is an invasive species that disrupts the normal vegetation composition that develops in and around settlements, and thus affects the functioning of ecosystems in general. Since it has no natural enemies, its pollen is singled out as the dominant allergen in the region. Bearing this in mind, the project aims at improving the environmental conditions in AP Vojvodina and Bács-Kiskun County (Baja) through prevention of further expansion of ambrosia. Specific objectives are: 1) Reduction in presence of allergen plant-ambrosia, through mechanical-chemical treatment in urban and rural areas–short-term perspective 2) Awareness raising and educating of target groups and informing the community about negative effects of ambrosia–long-term perspective 3) Continual monitoring of the area and control of presence of ambrosia pollen in the air-long-term effects. Several results will be achieved: 1) Removed ambrosia in project areas 2) Education and awareness of target groups raised 3) Joint database created with data on areas under ambrosia and pollen concentration in the air. The main activities are: mechanical/chemical treatment of ambrosia; measurement of pollen concentration in the air; data acquisition; education with dissemination; awareness raising; and project management. Achievements: Ragweed (ambrosia) allergy is a widespread condition which affects and incapacitates a large number of people. The seasonal increase in the concentration of ambrosia is a big problem in both Hungary and Serbia. This plant knows no borders, so the project partners came together to work on finding a cross-border solution. The project succeeded in achieving its aims: improvement of the environmental conditions in AP Vojvodina and Bács-Kiskun County (Baja) by preventing ragweed from spreading further. The activities involved mechanical and chemical treatment of ambrosia, measurement of pollen concentrations in the air, data acquisition, awareness raising and education of target groups and informing the community about the negative effects of ambrosia. The project partners have begun removing ragweed in several locations as planned, and they have established measurement stations in the programme area, in order to gain relevant information about air contamination by ragweed and other pollutant plants. After the project, the count of ambrosia pollen in the border region was lowered, especially in Sombor, where it decreased by more than 50% in August 2013 in comparison to the values before the project start. The project attempted to solve a common problem that can only be solved by joining forces. The results of the hard work are reliable and up-to-date data on air pollution, a higher level of awareness among the population in the border region, new personal and professional contacts between the authoritiesand last but not least a better quality of life.