Stimulating innovative and entrepreneurial mindsets of students, in particular, but not exclusively, for the set-up of new micro-companies, is a major concern of the EU educational policies in order to enhance the EU competitiveness mainly in the field of new technologies. This can be fostered by an effective use of Serious Gaming. The emerging paradigm in Technology Enhanced Learning (TEL) is considered particularly promising since Serious Games (SGs) can present users with realistic and motivating challenges and highly stimulate their information processing capabilities by providing immediate feedback and by capturing their concentration span for a long duration. The consortium is composed of the coordinator of Games and Learning Alliance (GaLA) and other partners belonging to GaLA and representing the excellence in TEL and SGs for management and business.The goal of eSG is to develop, deploy and assess experimental pedagogical plans based on appealing and instructive SGs for stimulating entrepreneurship in university students (a short course will be implemented for all 3 levels: Bachelor, Master, PhD), with an aim to reduce the gaps among education, research and innovation. An online planning tool will also be developed. The project is highly innovative because it brings to the Higher Education (HE) sector (also through teacher training) the results of ongoing research on SGs, in particular through GaLA, which acts as a hub at EU level. Further, the outcomes from the eSG’s extensive deployment – the first one of this type in EU, to the best of our knowledge – will provide precious experimental information to researchers that lack data on using SGs in real HE settings. Moreover, innovation is guaranteed by the focus on new technologies and entrepreneurship encouraging students to make use of their competences/skills and innovative knowledge gained in university studies in the real world of business.