The purpose of this PoC project is to develop a prototype of portable, highly sensitive and low cost technology for point-of care detection of inflammatory diseases biomarkers. At DTU Nanotech we have developed a completely new technology which holds a great potential to become, in a short period, an extremely useful tool for small medical facilities, family doctors, and chronically ill patients. The core readout element is represented, as in the HERMES project, by an optical pickup head, as used in CD, DVD-ROM or BLU-RAY, which embeds in a single optical path both a laser source and a high-resolution photodetector. By measuring how the light is scattered by magnetic nano-particles actuated by an external AC field we have demonstrated that it is possible to detect low concentration of analytes present in the sample. The key feature of our invention is that blood preconcentration and analyte readout are integrated into the same magnetic-based operations, leading to a compact, low-cost and user-friendly device. Doctors will benefit from our technology which allows performing multiple analyses without relying on centralized laboratories. A fast technology capable to detect multiple parameters would for example allow patient screening at the family doctors’ offices, or would allow chronic diseases patients to be monitored without the need of regularly going to the hospital. The scope of the project is both to provide a benchmarked prototype and to identify the best approach to commercialize the invention. The PoC grant will provide the instruments for understanding the low-cost point-of-care market more deeply, in order to start addressing as soon as possible the challenges of breaking through a complex market such as human diagnostics. Thanks to the intrinsic low-cost of the machine components, several cycles of production/testing/evaluation are expected to be performed, facilitating a constant and fast improvement of our platform development and testing.