The large scale research facilities and technology platforms are usually defined as a set of experimental instruments and components that are available mainly to academics and to a certain extent to industrials. The management of open access for researchers and world-class research programmes between these facilities is under consolidation through existing programmes like Instruct, EuroBioimaging. Large companies have created strong collaboration with these facilities but there is still a place for improving the economic outputs of this research and the involvement of SMEs in creating value and employment from these early scientific results. Photonics clusters and national platforms, as a strong link between Science and Economy, as well as between the regional and international environments, will play a key role in the organization of the collaboration between these facilities and the European SMEs. 7 European countries (France, UK, Germany, Sweden, Netherlands, Italy, Spain) gathered 70% of the new infrastructures in Life Sciences in last FP7. Nine photonics clusters from these countries, involved in initiatives supporting Biophotonics at the regional or national level define the 30-months OASIS Support Action. The consortium will realise an inventory to geographically map the former European investments made in Photonics Life Science facilities, to make them more easily accessible to SME. Targeting the right facilities is a prerequisite for efficient innovation but the right definition of further collaboration is still a challenge. OASIS partners will design services to improve collaboration framework between facilities, SMEs, hospitals, industrials in product development and validation. These actions should bring Europe SMEs a competitive advantage in new product development and a faster access to their markets by increasing available funding on these technologies and by reducing both cost and time of technical development.