The synthesis of nanostructured mesoporous polyoxometalates with high internal surface area and ordered or/and hierarchical pore structure remains an open challenge. This proposal aims to the development of such nanostructures. On one hand mesoporous materials with well-defined pore structure and high internal surface area are of great scientific and technological interest because of the possibility of tailoring their pore structure and framework composition. On the other hand metal-oxygen cluster anions of the early transition metals, commonly referred to as polyoxometalates and transition metal-substituted polyoxometalates, are important supramolecular inorganic nanoclusters with wide range of chemical structures and physicochemical properties and, thus attractive for applications such as photocatalysts, redox catalysts, electrochemical sensors and magnetic and optoelectronic devices. It would be very interesting to combine the shape selectivity of a mesoporous solid with the catalytic, optoelectronic and magnetic properties of a polyoxometalate cluster. Polyoxometalate clusters can provide novel building blocks, when they became nanostructured, promising new type of multifunctional nanomaterials We intend to establish new synthetic strategies toward nanostructured polyoxometalate-based mesoporous materials with well-defined pore structure and high internal surface area. For example purely inorganic and organic-supported nanostructured POM-based materials such as SiO2-, TiO2-, Al2O3-, SnO2-POM and {Q}-POM (where (POM= [(Mn,Ni)Mo9O32]6-, [(Co,Zn)PW11O39]5-, [(Eu)W10O36]9- and Q= 4,4-bipyridine, [Ag2(CH3CN)4]2+, (R’O)3SiRSi(OR’)3) will be explored. Integration of these POM nanostructures in thin film morphology will also be attempted. The resulted mesoporous polyoxometalates are expected of considerable performance in catalytic applications in reduction-oxidation of pollutant NOx and SOx gases and in epoxidation/oxidation of alkanes and alkenes.