The main aim of NANOMICEX project is to reduce the potential risk upon workers’ exposure to the engineered nanoparticles employed in the operative conditions of the inks and pigments industry, by addressing at the health and environmental consequences associated with the inclusion of nanoadditives within all stages of nanotechnology based products (production, use and disposal). To achieve it, new surface modifiers will be designed and developed to obtain less hazardous and more stable nanoparticles. The proposed work will focus on a selected set of nanoparticles relevant to the ink and pigment sector. Full characterisation will be carried out, followed by an exposure measurement in order to characterise and quantify any potential particle release in the production and processing activities. A comprehensive hazard assessment will allow the evaluation of effects on human and environmental models with comparisons between simple and modified nanoparticles carried out. Results from the assessment studies will be used to compile a risk assessment of the use of nanoparticles in the ink and pigment industry, and comparisons will be made with surface-modified nanoparticles. An evaluation of the effectiveness of risk management measures will be undertaken in order to select and design practical and cost effective strategies, which will be easy to implement in the real operative conditions. As part of this assessment, we will conduct a life cycle assessment, by evaluating their impacts during the whole process of manufacture, use and disposal of these products.The project results will involve industrial partners, providing an integrated strategy to mitigate the risk of workers dealing with nanoparticles, considering all relevant worker exposure scenarios. Furthermore, NANOMICEX will provide industrial stakeholders and the general public with appropriate knowledge on the risks of nanoparticles and nanoproducts, establishing synergies with the EU nanosafety infrastructure.