ImaGenX is a cross-border network of users, health providers, administrators, and researchers from Sicily and Malta tasked to promote Breast Cancer surveillance. By integrating interdisciplinary expertise in epidemiology and molecular genetics and through client empowerment it aims to strengthen the structured care and surveillance of women at risk from breast cancer. Risk assessment, stratification and allocation of an appropriate surveillance programmes will be strictly evidence-based. Sophisticated risk evaluation undertaken by user-friendly computer-based e-assessments and algorithms, and community specialist counselling will complement existing Breast Screening. ImaGenX will create an infrastructure to scrutinise putative environmental and genetic factors involved in malignancies in the central Mediterranean. Health initiatives such as preventive educational campaigns, medical or biochemical interventions, and bespoke IT screening will be precisely targeted. Communities will take greater responsibility for their health. ImaGenX seeks to innovate by introducing state-of-the-art technologies and rationalise traditional resources from regional bodies. It will consolidate existing scientific potential from two prime Mediterranean regions into Research Institutes of Excellence. Acting synergistically as strategic platforms they will transform their Life Sciences and Information Technology resources into world class industries engaged in cancer risk-reduction.ImaGenX è una rete transfrontaliera di utenti, operatori sanitari, amministratori e ricercatori siciliani e maltesi individuati per promuovere un programma di prevensizione del cancro al seno attraverso l'integrazione delle competenze interdisciplinari in epidemiologia e genetica molecolare. Il progetto creerà le infrastrutture necessarie per monitorare i fattori putativi di tipo ambientale e genetico coinvolti nell'insorgenza di tumori maligni nell'area del Mediterraneo centrale. Iniziative sanitarie, campagne di formazione preventiva, IT screening biochimici e diagnostici nonchè interventi medici mirati avranno lo scopo di incoraggiare le comunità ad assumersi maggiori responsabilità circa le politiche di prevenzione del cancro. Il progetto mira a consolidare il potenziale scientifico già esistente nei due territori creando sinergie che favoriscano l'impegno nella riduzione e nella cura dei tumori Achievements: Guided by the Screening Unit of the Ministry for Energy and Health of Malta, the projects partners dealt with monitoring the life style and the environmental and genetic profile of Sicilian and Maltese women of any age to identify possible genetic mutations and thus outline common elements in the women examined so as to trace a mathematical model that reliably evaluates the main risk factors of breast cancer.After the formulation of the model, the partnership set about devising an app for smartphones. Through the use of this app Sicilian and Maltese women will be the first to really become aware of the risks and consequences of developing breast cancer and will thus be able to take into consideration a change in their habits to steer clearof, or minimise the risk factors. Such a decision, thanks to raising awareness and information received through the app, could help young women (especially where there is a family history) avoid far graver consequences.The creation of this valuable instrument of information and control and its widespread use among an increasing proportion of women in the cross-border area is real progress, both in the health and social fields, and it is enabling the ight against this terrible disease.Guided by the Screening Unit of the Ministry for Energy and Health of Malta, the projects partners dealt with monitoring the life style and the environmental and genetic profile of Sicilian and Maltese women of any age to identify possible genetic mutations and thus outline common elements in the women examined so as to trace a mathematical model that reliably evaluates the main risk factors of breast cancer.After the formulation of the model, the partnership set about devising an app for smartphones. Through the use of this app Sicilian and Maltese women will be the first to really become aware of the risks and consequences of developing breast cancer and will thus be able to take into consideration a change in their habits to steer clearof, or minimise the risk factors. Such a decision, thanks to raising awareness and information received through the app, could help young women (especially where there is a family history) avoid far graver consequences.The creation of this valuable instrument of information and control and its widespread use among an increasing proportion of women in the cross-border area is real progress, both in the health and social fields, and it is enabling the ight against this terrible disease.