The proposed project aims to develop innovative methods, tools and concepts for the replacement of copper in European organic and low input fruit, grapevine, potato, and tomato production systems. Copper-free production systems will be achieved by (i) providing alternative compounds, (ii) ‘smart’ application tools and (iii) by integrating these tools into traditional and novel copper-free crop production systems. The copper-free apple, grapevine, potato and tomato production systems will be (iv) evaluated in a multi-criteria assessment with respect to agronomic, ecologic and economic performance. CO-FREE will also develop strategies to develop (v) ‘smart’ breeding goals by development of crop ideotypes and (vi) foster consumer acceptance of novel disease-resistant cultivars by consumers and retailers. By involving farmers, advisors, plant protection industry, policy makers and researchers as well as the stakeholders of the European organic and low input sector (food supply chain, retailers, producers associations), CO-FREE will ensure a rapid development, dissemination and adoption of the copper replacement strategies. The multidisciplinary consortium proposed for the project includes 11 academic and 9 industry (all SMEs) partners from 10 European countries. All partner institutions are leaders in their respective fields and/or are leading providers of advisory services to farmers, retailers, policy makers and other stakeholders in the organic and low input sector.