Impact of Proteasome Subpopulations on Cardiac Remodeling
(PROCARE)
Start date: Jan 1, 2012,
End date: Dec 31, 2015
PROJECT
FINISHED
Heart disease is the number one cause of death in Europe and the world. Cardiac remodeling involving cardiac hypertrophy is associated with higher morbidity as well as mortality due to heart disease. Cardiac muscle mass is potentially influenced by the ubiquitin proteasome system (UPS). At the heart of the UPS is the proteasome, which specifically degrades targeted proteins into peptides. The candidate has identified that the cardiac proteasomal core, the 20S proteasome, is a heterogenic group of highly similar multiprotein complexes with different functionality. During the development of cardiac hypertrophy, the assembly and thus the composition of 20S proteasome complexes is distinctly regulated. In consequence, proteasomal activities change non-uniformly. The objective of the proposed study is to analyze the impact of this regulatory mechanism on cardiac remodeling.
Get Access to the 1st Network for European Cooperation
Log In
or
Create an account
to see this content
Coordinator
UNIVERSITAETSKLINIKUM HEIDELBERG
€ 100 000,00- Thomas Eisenhauer
- IM NEUENHEIMER FELD 672 69120 HEIDELBERG (Germany)
Details
- 100% € 100 000,00
-
FP7-PEOPLE
- Project on CORDIS Platform