It is a fact that entrepreneurship is a underrepresented skill in secondary schools, being this one of the crucial skills in today's world, as stated by the European Commission and other international institutions. Moreover, when facing gender perspective, research reports show that girls tend to have less motivations in becoming future entrepreneurs. We believe that ICT can provide a flexible and potential motivational environment for empowering these young women in their future choices, their studies and jobs. There is a need to add knowledge to secondary school girls' enthusiasm and teach them to develop their critical thinking together with their imagination. This will result in new and useful ideas that will surprise all of us and can make them life entrepreneurs. ICT can be both a motivational and diverse way to achive it, as well as a promising job market for future female entrepreneurs.With this initiative, we propose to design, carry out and evaluate an innovative program to enhance entrepreneurship skills among secondary school girls, by using ICT as the key element. It is aimed at empowering girls with the knowledge, skills and values to help them be able to create future opportunities for innovation and quality ICT related employment.This project will involve relevant actors in this sector, (schools, universities, teacher training institutions, ICT research centres, educational administrations) in Europe and outside to combine efforts to propose an effective methodology to tackle this problem and with connections to maximize the impact of the initiative in their countries and at a European level. Its methodology and activities are directly aiming at supporting the achievement of several Key competences for lifelong learning as stated in the European Framework among secondary school girls, mainly: 7 Entrepreneurship, 4 Digital Competence, 3 Math literacy, 2 Communication in foreign languages.