For the first time, more than 50% of the world's population live in urban areas. By 2050, c. 70% of people are likely to be city dwellers, compared with less than 30% in 1950. This trend brings with it increased security and safety threats in urban areas, not least to urban built infrastructure. The central aim of HARMONISE (A Holistic Approach to Resilience and Systematic ActiOns to Make Large Scale UrbaN Built Infrastructure SEcure) is to develop a comprehensive, multi-faceted, yet mutually-reinforcing concept for the enhanced security, resilience and sustainability of large scale urban built infrastructure and development.Large scale urban built infrastructure is a critical component within the intertwined networks of urban areas, which include not only physical components, but also integrated hardware and software aspects. To date, a comprehensive and holistic approach to improve the resilience and security of large scale urban developments (i.e. shopping centres/areas, sports venues or business centres with underground transportation nodes) against attacks and disruptions, has not been developed thoroughly.HARMONISE will be grounded in a holistic view of innovation, and will advocate synergies with, and augmentation of, relevant existing, past or ongoing projects. The project recognises the necessity to improve the design of urban areas and increase their security against, and resilience, to new threats. Specifically, HARMONISE seeks to deliver (a) a holistic urban resilience integrated information platform; (b) a suite of innovative tools (toolkit hosted within the HARMONISE platform); (c) greater understanding and awareness of urban security and resilience vis-a-vis dissemination activities; and, (d) commercialisation opportunities among emerging new markets in this field. HARMONISE will result in significant resilience enhancement methods for large scale urban built infrastructure.