The project GRAIL has been build with 15 partners from 9 different countries with the aim of finalising the solutions given previously to the valorization of glycerol and transform then in valuable products in a biorefinery approachThe overall concept of GRAIL project is the use, exploitation and further development of the state of the art in the field of bio-based products from glycerol and the development research-driven cluster for the use of crude glycerol for the production of high-value platforms, as well as valued end products, harnessing the biotech processes. Therefore GRAIL project has a strong business focus and its ultimate goal is to set up implantation of biorefineries in close relationship with biodiesel.This project's aim is to develop a set of technologies for converting waste glycerol from biodiesel production in a biorefinery concept to end with products of high value such as 1,3 propanediol, Fatty acid glycerol formal esters, PolyHydroxyAlkanoates (PHA), Hydrogen and Ethanol, Synthetic coatings, powder coating resins, Secondary Glycerol Amine, Biobutanol, Trehalose, Cyanocobalamin (Vitamin B12), ß-carotene, Docosahexaenoic acid (DHA), … .The GRAIL project has designed an overall strategy based on three main pillars covering all the value chain:Pillar 1: Raw materials: Evaluation of crude glycerol and purificationPillar 2: Product development: Research and development to transform crude glycerol into other high added value such as biofuels, green chemicals and food supplementsPillar 3: Industrial feasibility aspects including economic and environmental evaluation. This pillar will take the results of GRAIL from the product development to the industrial site. To carry out that the technical feasibility will be study on a pilot plant in a Demonstration (and the results will be important to evaluate the LCA and the economic feasibility (WP6).