EAU4Food seeks to address the need for new approaches to increase food production in irrigated areas in Africa, while ensuring healthy and resilient environments. Potential pitfalls of introducing innovations in local farming systems, like limited adoption by farmers and trade-off effects to other (environmental) systems are overcome by, respectively, i) utilizing a true transdisciplinary approach, which involves the active participation of all stakeholders in all relevant disciplines, and ii) by determining and respecting so called sustainable production thresholds. EAU4Food is executed in four irrigated areas in Africa, viz. Southern Africa (Mozambique and South-Africa), Tunisia, Mali and Ethiopia to fully benefit from the potential of cross distributing promising strategies and innovations. At each site, key indicators, risk factors, farm strategies and biophysical parameters are monitored for identification of current constraints to food production and to evaluate agro-ecological and socio-economic impacts of improved practices and/or innovations after implementation. Results of EAU4Food are distilled into tailor made support tables and guidelines for different user groups. These support tables and guidelines support decision making processes at local level by overseeing short-term and long-term effects of alternative practices and improved strategies. EAU4Food is expected to have significant positive impacts on agricultural production at farm level for many years to come, and on wider policy processes at national and trans-national levels. To enlarge and maintain the impact of EAU4Food, capacity building programmes are developed at different levels, going from farmer to farmer exchange up to exchange of scientific personnel. Moreover, further exploitation of the results of EAU4Food is supported via other mediums such as ‘songs of success’, documentaries, school programmes, policy briefs, fact-books and scientific publications and presentations.