eDIGIREGION is a unique collaborative project that brings together a balanced blend of complimentary and experienced partners from four diverse regions. The sixteen (16) people involved in formulating this proposal are senior executives and decision makers in their respective organisations. These partners have embarked upon, are committed to, and have already demonstrated the power of transnational collaboration and cooperation by jointly conceptualising and articulating eDIGIREGION’s vision, and preparing this proposal.The ultimate aim of eDIGIREGION is to enhance regions’ sustainable competitiveness by exploiting their strengths and smart specialisations to realise the Digital Agenda within a regional domain. This will be achieved by increasing the interoperability between the triple helix of regional actors (government, research centres and universities, and industry) to define and action region specific Joint Action Plans (JAPs). Through a planned process of inter and intra-regional mentoring, the eDIGIREGION project will also facilitate transnational and international collaboration leading to the creation of an inter-regional Joint Action Plan (iJAP). As well as increasing transnational collaboration, cooperation, knowledge and technology transfer, and the sharing of resources, the JAPs will align regional RTD, innovation, and economic policies, strategies and practices.A unique aspect of this project is the live testing of the JAPs by facilitating regional actors (researchers, SMEs, government agencies and funding agencies) to bring technology through the innovation process.The lasting legacy of the eDIGIREGION project is an electronic central repository, accessible to all regional stakeholders across the EU, that will contain all the methodologies, techniques and case studies that will enable EU regions to enhance their sustainability and competitiveness through realising the Digital Agenda within their own domains.