"The proposed project ECNIS2 aims at continuing the integrative and coordinative works initiated during ECNIS network with an ultimate goal of transforming network into a virtual centre, the European Centre for Research and Education on Cancer, Environment and Food (ECRECEF).ECNIS has already laid foundations for the development of the centre by bringing together researchers from different disciplines (epidemiology, chemical analysis, genetics, molecu¬lar biology, nutrition, exposure assessment, risk as¬sessment, harmonisation and standardisation of methodologies and analytical techniques). The initiatives undertaken within ECNIS will be continued during ECNIS2 and will focus on the main pillars, so called “ECNIS added values” including: Molecular Epidemiology and Cancer"" (MEC) database, Core facilities for: standardized chemicals, antibodies and analytical methodology, European Standards Committee on Urinary DNA Lesion Analysis (ESCULA), and European Comet Assay Validation Group (ECVAG), ECNIS Repository, and Training and educational program. The works of as many as 21 ECNIS2 partner institutions from 13 countries (incl. 4 SMEs) will be organized within the framework of nine workpackages, five Infrastructural (WP1-ECNIS Centre establishment; WP2-Validation and Standardization; WP3 – MEC database; WP4 – Spreading of Knowledge; WP5- Education and training), three Thematic (WP6 - Biomarkers use for cancer prevention; WP7 - Dietary exposure and cancer risk as modified by genetic polymorphisms; WP8- Ethics, Communication and Gender) and Managerial –WP9.Research coordination, education and dissemination will be key outputs, together with the formulation of strategy for transformation of ECNIS into the Centre (ECRECEF).ECNIS2 will facilitate the transformation of a dynamic European consortium into a durable structure of the co-ordinating centre."