EO2HEAVEN contributes to a better understanding of the complex relationships between environmental changes and their impact on human health. The project will monitor changes induced by human activities, with emphasis on atmospheric, river, lake and coastal marine pollution. EO2HEAVEN will follow a multidisciplinary and user-driven approach involving public health stakeholders who will work closely with technology and service providers in both the earth observation and in-situ environmental monitoring domain. The result of this collaboration will be the design and development of a GIS based upon an open and standards-based Spatial Information Infrastructure (SII) envisaged as a helpful tool for research of human exposure and early detection of infections. The key factors of the EO2HEAVEN system will be 1) an enhanced integration of remotely sensed and in-situ environmental measurements, and 2) the development of models to relate these environmental data to exposure and health data. Both factors will directly address current goals of GEOSS such that the resulting system will be integrated into the GEOSS infrastructure after successful validation already during the course of the project. Throughout the life span of the project the stakeholder requirements from three different use cases (in Europe and Southern Africa) will be assessed and the technical solutions proposed by EO2HEAVEN will be evaluated through an iterative process, thus ensuring that the solutions can be applied on a global scale. EO2HEAVEN will specify and implement the SII as an open architecture based upon international standards and adaptive geospatial Web services in alignment with the large-scale initiatives INSPIRE and GMES. The SII will include bridging capabilities at the syntactic and semantic levels to and between environmental and health systems. Ongoing and recently completed research projects in the ICT, environmental and health domains will be studied and used in an integrative approach.