Creativity and innovation as well as entrepreneurship are the key to sustainable economic and social development. They are as well indispensable in overcoming global challenges that will happen in following years. In the project "Knowledge for Development" we want to develop model for developing key competence (KC) of a sense of initiative and entrepreneurship in the curriculum of general high school program. Today, there are 5.5 million unemployed young people in the EU. Apart from the economic crisis, the reason is also in the insufficient education and lack of skills of young people. Cooperation between schools and the local economy is rare, so the schools can not respond adequately and on time to the needs of the environment. The knowledge acquired by students is often incomplete and theoretically, young people do not know how to transfer it to new situations. The students don’t have the ability to turn ideas into action. More and more young people see themselves as victims of current circumstances and hope only for government assistance. Many EU documents reveal that the part of the solution is development of skills, including the KC sense of initiative and entrepreneurship in all sectors of education. Currently, there are some good models for the development of these SK, but these are limited to the vocational and technical education as well as to the simulated establishment and management of individual companies. But there is no satisfying model that would allow the development of SK in general education, where this competence is broader to understand. Therefore in the project "Knowledge for Development" a model for the development of KC entrepreneurial spirit and initiative through the curriculums for high schools is developed. It is about the opportunity to develop these skills in all subjects in regular classes. In the project teaching methods are developed and tested, which make it possible to make such learning process that students develop their creativity, self-motivation and goal-orientation. They learn to generate ideas, make decisions and deal with their consequences. But this is only possible if the teachers are trained. One part of the model is the close cooperation between the school and the local environment, the application of academic knowledge in real-world solutions to problems of the local economy. Objectives that are followed: - Promote entrepreneurship, initiative and creativity, - To develop other skills that will help the students in the labour market - Connection of the knowledge of the various disciplines, - Trained teachers for the development of SK initiative and entrepreneurship, - Exchange of experiences between partner schools and wider, - Strengthening the role of the school as a catalyst for development in the local environment, - Setting up of solid connections between education and the economy, - To direct students to courses that lead to shortage occupations. To achieve the objectives, three general-education schools have joined: - Gimnazija Ptuj (Slovenia) that has a lot of experience with the management of EU projects, - Alpe-Adria High School Völkermarkt (Austria) that has experience with the model Entrepreneur's, collaborates with the Chamber of Commerce and is very active in many international connections - II. gimnazija Osijek (Croatia) is very competent because of the professionals who are involved in analysis and the development of teaching materials. Long-term impact of the project : - At the local level : Linking schools and industry , strengthening entrepreneurship , development of the professional needed by the environment, consequently lower unemployment rate ; - At the national level : the model can be applied to all general high schools and may represent a systematic solution ; - At the European level : International and interdisciplinary cooperation, which is of enormous importance for the development of the EU's dynamic , competitive economy, development of underdeveloped regions , the exchange of ideas and effective practices across regional and national borders , the strengthening of the European consciousness, the development of social competence, civic competence and the foreign linguistic competence and creative and entrepreneurial young people who have no burden of their own countries, but create new opportunities for themselves and others with their own activities and ideas.