CHAIN-REDS vision is to promote and support technological and scientific collaboration across different eInfrastructures established and operated in various continents, in order to facilitate their uptake and use by established and emerging Virtual Research Communities (VRCs) but also by single researchers, promoting instruments and practices that can facilitate their inclusion in the community of users. The project aims to support and disseminate the best practices currently adopted in Europe and other continents, and promote and facilitate interoperability among different regional eInfrastructures. CHAIN-REDS gathers the main stakeholders of regional eInfrastructures, collectively engaged in studying and defining a path towards a global eInfrastructure ecosystem that will allow VRCs, research groups and even single researchers to access and efficiently use worldwide distributed resources (i.e. computing, storage, data, services, tools, applications). The core objective of CHAIN-REDS project is to promote, coordinate and support the effort of a critical mass of non-European eInfrastructures for Research and Education to collaborate with Europe addressing interoperability and interoperation of Grids and other Distributed Computing Infrastructures. From this perspective, CHAIN-REDS will optimise the interoperation of European infrastructures with those present in other 6 regions of the world, both from development and use point of view, and catering to different communities.Overall, CHAIN-REDs will provide input for future strategies and decision-making regarding collaboration with other regions on eInfrastructure deployment and availability of related data; it will raise the visibility of eInfrastructures towards intercontinental audiences, covering most of the world and will provide support to establish globally connected and interoperable infrastructures, in particular between EU and the developing regions.