The proposed Knowledge Alliance (KA) aims at competencies needed for a sustainable socio-economic development and for sustainability driven enterprises. We want to change the EU landscape of HEIs towards a stronger accentuation on new inter- and transdisciplinary ways of teaching and learning, sustainable entrepreneurial education and increasing university-business cooperation in the context of a “green economy”. This shall be achieved through the framework and basic elements of a new Joint Master Program on “Sustainability Driven Entrepreneurship, Policies and Innovation” for European universities. The framework is based on four educational modules focussing on: 1) Sustainable socio-economic development 2) Sustainability driven enterprises 3) Eco innovations and environmental management and 4) Environmental policies and networks. Each module could also be used as “stand-alone” to offer universities substantial support and guidance.The structure of every module is aiming at acquirement of skills and competences via using inter- and transdisciplinary methods and tools in teaching and learning, focusing university business cooperation and project work and implementation aiming at entrepreneurial education and founding new sustainability driven enterprises.5 regional pilots which form an inter-university course with more than 25 service learning projects (and 25 service learning partners / enterprises) will test and optimise the modules while providing various best practice examples of university-business cooperation.At the end of the proposed project, an open access knowledge platform will provide the four modules and shall account and enable European universities for the implementation of the Joint Master and for their own curricula building processes. This knowledge platform will be linked with and supported by global multipliers such as the UNU / global RCE network or the COPERNICUS Alliance in order to sustain the activities and partnership of the proposed KA