B-CROSS project aims are the development of a Business Cooperation Network among Chambers of Commerce and Industry in CADSES and other INTERREG III B co-operation areas, that will use a Business Cooperation One Stop Shop (B-CROSS) to support and enforce Business Cooperation among SMEs in the involved countries. B-CROSS takes advantage of the existing experience and special know-how on ICT technology, ICT services offered by Chambers and Business Cooperation available in the partnership. B-CROSS includes mechanisms for connecting to different Chamber ICT systems where the existing business digital content is available. Other special services that will be developed will include services for the presentation of the regional characteristics and offered opportunities, user friendly tools to help SMEs create small product and company profiles, integrated transnational business catalogues and yellow pages, synchronous and asynchronous collaboration tools, and training services, among others. B-CROSS works as the tool to promote market opportunities, and match Offer- Demand of Products and Services to support SMEs towards business cooperation. During the course of the project the CCI network that will be developed, will include experts from other Chambers or related business efforts, so B-CROSS will be easily expanded with the entrance of new regions, (through the respective Chambers, SMEs Associations), and new applications. The large investment after the end of the project will be studied in the Business plan that the B-CROSS CCI network will publish. Achievements: The creation of a business co-operation network was promoted as the business one-stop shop for the areas involved. Offering valuable information it soon became established as a business tool for SMEs for offering market opportunities and attracting foreign investors. The co-operation network and the available telematics services and content-based services supported SMEs especially in rural areas in effectively promoting their products and using the business offerings and demand-matching B-CROSS platform to form business partnerships and attract foreign business partners. Through the development of this network and the use of a modern ICT platform and services, SMEs, especially in rural areas, can develop their business activities and business range, directly affecting the economic and social development in their regions and raise awareness of IT applications. Through the involvement of the chambers of commerce and SME staff in e-business methods and in e-training and e-meeting activities, equal opportunities were promoted especially in rural areas. The resultant economic and social development contributes to the spatial development. The B-CROSS network and platform may be expanded to cover a wider territory and can easily be expanded to include Eastern European countries which are not EU Member States.