The focus of LOLA is on access-layer technologies targeting low-latency robust and spectrally-efficient transmission in a set of emerging application scenarios. We consider two basic types of wireless networks, namely long-range LTE-Advanced Cellular Networks and medium-range rapidly-deployable mesh networks. Research on low-latency transmission in cellular networks is focused firstly on transmission technologies in support of gaming services which will undoubtedly prove to be a strategic revenue area for operators in the years to come. Secondly, we also consider machine-to-machine (M2M) applications in mobile environments using sensors connected to public infrastructure (in trains, busses, train stations, utility metering, etc.). M2M is an application area of extremely high growth potential in the context of future LTE-Advanced networks. A primary focus of the M2M research is to provide recommendations regarding PHY/MAC procedures in support of M2M to the 3GPP standardization process. The rapidly-deployable mesh topology component addresses M2M applications such as remote control and personnel/fleet tracking envisaged for future broadband civil protection networks. This work builds upon ongoing European research in this important area. Fundamental aspects of low-latency transmission are considered in addition to validation on real-time prototypes for a subset of the considered application scenarios. The cellular scenario validation is carried out using both live measurements from an HSPA test cell coupled with large-scale real-time emulation using the OpenAirInterface.org emulator for both high-performance gaming and M2M applications. In addition, a validation testbed for low-layer (PHY/MAC) low-latency procedures will be developed. The rapidly-deployable wireless mesh scenario validation makes use of the real-time OpenAirInterface.org RF platform and the existing FP6 CHORIST demonstrator interconnected with commercial M2M equipment.