BioTiNet ITN is an inter-disciplinary, inter-sectoral and multinational initiative, which has the primary goal of training researchers who will help to improve the overall efficiency of metallic implants in orthopedic treatment by minimizing the stress shielding effect, and promote technical, biological and clinical developments at a pan-European level, for the benefit of all European inhabitants.BioTiNet ITN brings together 12 leading European research groups which possess state of the art expertise and excellent research infrastructures to provide opportunities for 18 young scientists to receive exceptional, high-level training in biomedical materials, with special emphasis on the development of novel low-rigidity Titanium-based structures for orthopaedic use. The project will screen and explore a wide structural spectrum with specific characteristics, balancing the advantages of a reduced Young’s modulus and the best resistance to deformation, which will help relieve problems with stress shielding. The novel Titanium-base structures will meet the end-user/customer requirements of biomechanical and biochemical functionality and also the material producers requirement of processing. The research program comprises four complementary research work packages, designed to deliver to the young researchers the most relevant state of the art knowledge and expertise in the biomaterials research field for a career development in line with the scientific, industrial and societal needs and challenges.Network-wide and local research training activities, training in complementary skills dedicated to biomaterials field (entrepreneurship, ethics, communication, innovation, IPR, project management etc.) and the cooperation with industrial partners will guarantee the complete training in this scientific field of a new generation of scientists, thus allowing them to become European professionals with excellent career perspectives.