Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

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Cracking the epitranscriptome (CrackEpitranscriptom)

Start date: Nov 1, 2016, End date: Oct 31, 2021,

Over 100 types of distinct modifications are catalyzed on RNA molecules post-transcriptionally. In an analogous manner to well-studied chemical modifications on proteins or DNA, modifications on RNA - and particularly on mRNA - harbor the exciting potential of regulating the complex and interlinked life cycle of these molecules. The most abundant modification in mammalian and yeast mRNA is N6-meth ...
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Neural basis of natural navigation: Representation of goals, 3-D spaces and 1-km distances in the bat hippocampal formation – the role of experience (NATURAL_BAT_NAV)

Start date: Nov 1, 2016, End date: Oct 31, 2021,

... rodents and bats navigate over kilometer-scale distances. Nothing is known about how the brain supports such real-life navigation. We will utilize a 1-km long test facility at the Weizmann Institute of Science, and record place cells and grid cells in bats navigating over biologically relevant spatial scales. Further, we will compare neural codes for space in wild-born bats versus bats born in t ...
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Host-virus chemical arms race during algal bloom in the ocean at a single cell resolution (Virocellsphere)

Start date: Nov 1, 2016, End date: Oct 31, 2021,

Phytoplankton blooms are ephemeral events of exceptionally high primary productivity that regulate the flux of carbon across marine food webs. The cosmopolitan coccolithophore Emiliania huxleyi (Haptophyta) is a unicellular eukaryotic alga responsible for the largest oceanic algal blooms covering thousands of square kilometers. These annual blooms are frequently terminated by a specific large dsDN ...
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Beyond CRISPR: Systematic characterization of novel anti-phage defense systems in the microbial pan-genome (PhageResist)

Start date: Jul 1, 2016, End date: Jun 30, 2021,

The perpetual arms race between bacteria and phage has resulted in the evolution of efficient resistance systems that protect bacteria from phage infection. Such systems, which include restriction enzymes and CRISPR-Cas, have major influence on the evolution of both bacteria and phage, and have also proven to be invaluable for molecular and biotechnological applications. Although much have been le ...
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New Directions in Sustainable Catalysis by Metal Complexes (SUSCAT)

Start date: Jul 1, 2016, End date: Jun 30, 2021,

The discovery of novel sustainable catalytic reactions is a major current goal. Based on recent discoveries in our group, we plan to develop unprecedented sustainable catalytic reactions with special emphasis on reactions catalyzed by complexes of earth-abundant metals.We have recently discovered an intriguing reaction, namely the oxidation of organic compounds using water, with no added oxidant, ...
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Extremes in logarithmically correlated fields (LogCorrelatedFields)

Start date: Jun 1, 2016, End date: May 31, 2021,

The proposed research deals with the extremes of logarithmically correlated fields, in both the Gaussian and non-Gaussian setups. Examples of such fields are branching random walks, the (discrete) two dimensional Gaussian free field, the set of points left uncovered by a random walk on the two dimensional torus at times close to the cover time of the torus, the (absolute) values of the characteris ...
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Quantum fluids of photons in optically-induced structures (Q-PHOTONICS)

Start date: Jun 1, 2016, End date: May 31, 2021,

A variety of classical optical systems exhibiting rich and complex matter-like behavior have been explored in recent years. Unfortunately in the optical regime, photons – the fundamental constituents of light – do not interact strongly with one another, and therefore cannot be used for studying many-body effects. It is only in the extreme regime of quantum nonlinear optics where effective interact ...
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Revealing the ubiquitin and ubiquitin-like modification landscape in health and disease (Ubl-Code)

Start date: May 1, 2016, End date: Apr 30, 2021,

Post-translational modifications (PTMs) of proteins are a major tool that the cell uses to monitor events and initiate appropriate responses. While a protein is defined by its backbone of amino acid sequence, its function is often determined by PTMs, which specify stability, activity, or cellular localization. Among PTMs, ubiquitin and ubiquitin-like (Ubl) modifications were shown to regulate a va ...
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Colloidal Quantum Dot Quantum Optics (ColloQuantO)

Start date: May 1, 2016, End date: Apr 30, 2021,

Colloidal semiconductor nanocrystals have already found significant use in various arenas, including bioimaging, displays, lighting, photovoltaics and catalysis. Here we aim to harness the extremely broad synthetic toolbox of colloidal semiconductor quantum dots in order to utilize them as unique sources of quantum states of light, extending well beyond the present attempts to use them as single p ...
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Genetically Encoded Multicolor Reporter Systems For Multiplexed MRI (GeneREFORM)

Start date: May 1, 2016, End date: Apr 30, 2021,

In order to fully understand the complexity of biological processes that are reflected by simultaneous occurrences of intra and inter-cellular events, multiplexed imaging platforms are needed. Fluorescent reporter genes, with their “multicolor” imaging capabilities, have revolutionized science and their founders have been awarded the Nobel Prize. Nevertheless, the light signal source of these repo ...
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Cellular Dynamics of Intestinal Antibody-Mediated Immune Response (GutBCells)

Start date: May 1, 2016, End date: Apr 30, 2021,

Vaccination is widely used to prevent human diseases by inducing the formation of cellular and antibody-mediated immune responses for induction of long lasting immunological memory. Although most studies focus on immune responses elicited against injected immunizations, the simplest delivery of a vaccine regimen is by oral administration. The cellular and molecular components of the antibody immun ...
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Genetic and Small Molecule Modifiers of Lysosomal Function (LysoMod)

Start date: Mar 1, 2017, End date: Feb 28, 2021,

LysoMod will innovate in the area of personalized medicine for disorders linked to lysosomal dysfunction. This will be achieved by implementing a collaborative staff-exchange program between highly complementary and multidisciplinary academic and non-academic partners with expertise in pharmacology, medicinal chemistry, cell biology, biochemistry, mouse and human genetics, transcriptomics, proteom ...
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Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research (INSTRUCT-ULTRA)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale a ...
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Analysis, Design and Experimental Evolution of Novel Carbon Fixation Pathways (NOVCARBFIX)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Carbon fixation is a prerequisite for accumulating biomass and storing energy in most of the living world. As such, it supplies our food and dominates land and water usage by humanity. In agriculture, where water and nutrients are abundant, the rate of carbon fixation often limits growth rate. Therefore increasing the rate of carbon fixation is of global importance towards agricultural and energet ...
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Transforming the future of agriculture through synthetic photorespiration (FutureAgriculture)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

For a new green revolution to feed the continually increasing population, agriculture productivity will have to be significantly improved. Photorespiration represents a big challenge in this respect, because it dissipates energy and leads to the futile loss of CO2, thereby limiting plant growth yield. Implementing an efficient metabolic bypass for photorespiration can therefore increase the photos ...
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Nano Voltage Sensors (NVS)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

To understand how the brain works, tools need to be developed that will allow neuroscientists to investigate how interactions between individual neurons lead to emergent networks. Towards this goal, we will develop targetable voltage sensing nanorods that self-insert into the cell membrane and optically and non-invasively record action potentials at the single particle and nanoscale level, at mult ...
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Unravelling Fragile 1D Quantum States of Matter Through Ultra-sensitive Imaging (See-1D-Qmatter)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

In condensed matter physics there are several iconic predictions that have evaded experimental discovery for many decades. Well-known examples include the proposed fractionally-charged quasiparticles in one-dimension, the theorized quantum crystal of electrons, and the elusive Kondo cloud. These sought-after many-body states all share two key aspects underscoring why they are so hard to discover: ...
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VISUALIZATION OF TOPOLGICAL STATES IN PRISTINE NANOWIRES (TOPO-NW)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Topological phases of matter have been at the center of intense scientific research. Over the past decade this has led to the discovery of dozens of topological materials with exotic boundary states. In three dimensional topological phases, scanning tunneling microscopy (STM) has been instrumental in unveiling the unusual properties of these surface states. This success, however, did not encompass ...
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Exploiting light and material interaction (lightMaterInt)

Start date: Dec 1, 2015, End date: Nov 30, 2020,

The interaction between light and material leads to beautiful visual phenomena that greatly enrich our perception of the world. The ability to measure and model light scattering is central to almost any field of science. However, light transport in rich scenes is a complex process involving a long sequence of scattering events. Computationally modeling, reproducing and acquiring the processes gen ...
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Fibre break models for designing novel composite microstructures and applications (FiBreMoD)

Start date: Oct 1, 2016, End date: Sep 30, 2020,

Limiting the climate change-induced temperature increase to less than 2°C will require strong reductions in greenhouse gas emissions. Lightweight materials and fibre-reinforced composites in particular, are a key enabling technology to achieve this goal. Current composite applications are however strongly overdesigned due to a lack of reliable design tools and predictive models for their mechanica ...
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Social Chemosignaling as a Factor in Human Behavior in both Health and Disease (SocioSmell)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

"We test the working hypothesis that humans are constantly engaging in social chemosignaling, and that this serves as a major yet underappreciated force in shaping human social behavior. A major component of social chemosignaling in macrosmatic mammals is conveying of social status, namely dominance/submissiveness. We start by testing the novel hypothesis that humans similarly share information on ...
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Systematic exploration of peroxisomal structure and function (PeroxiSystem)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Peroxisomes are ubiquitous and dynamic organelles that house many important pathways of cellular metabolism. This key organelle propagates cellular signals for differentiation, development and metabolism, and thus it is no surprise that a large number of diseases, including metabolic disorders, have been linked to peroxisomal dysfunction. Despite the importance of peroxisomes many fundamental ques ...
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Expanding the Topological Frontier in Quantum Matter: from Concepts to Future Applications (TopFront)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Topological phases arise from a fascinating interplay between quantum mechanics and many-body physics. They exhibit an abundance of extraordinary properties, such as protected edge and surface modes, exotic particle statistics, and non-local correlations. These make them not only scientifically stimulating, but also appealing for ground-breaking future applications, such as quantum computing using ...
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Laying the Biological, Computational and Architectural Foundations for Human Cell Lineage Discovery (LineageDiscovery)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Within a decade, advances in single-cell genomics would allow humanity to embark on a coordinated international effort to discover the human cell lineage tree. The goal of LineageDiscovery is to lay the biological, computational and architectural foundations for this envisioned project and demonstrate its feasibility and value.An organismal cell lineage tree is a rooted, labelled binary tree where ...
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Unraveling changes in cellular gene expression during viral infection (Profile Infection)

Start date: Jun 1, 2015, End date: May 31, 2020,

The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation. Identifying the pathways that the virus relies on or subverts is of great inter ...
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Sequence and Function Relationships in Long Intervening Noncoding RNAs (lincSAFARI)

Start date: Jun 1, 2015, End date: May 31, 2020,

It is now clear that many intergenic regions in eukaryotic genomes give rise to a range of processed and regulated transcripts that do not appear to code for functional proteins. A subset of these are long (>200 nt), capped and polyadenylated RNAs transcribed by RNA polymerase II and collectively called long intervening noncoding RNAs or lincRNAs. The recent estimates are that the human genome enc ...
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Deciphering the role of adult neurogenesis in hippocampal memory codes by optically imaging neuronal activity in freely behaving mice (NeurogenesisCode)

Start date: May 1, 2015, End date: Apr 30, 2020,

The hippocampal dentate gyrus (DG) is one of the few areas in the adult mammalian brain that exhibits neurogenesis, the continuous generation of new neurons. Much evidence indicates that adult neurogenesis contributes to hippocampal-dependent cognition, but the nature of this contribution remains elusive. I envisioned that the clearest path towards understanding the function of adult neurogenesis ...
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Distributed Biological Algorithms (DBA)

Start date: May 1, 2015, End date: Apr 30, 2020,

This project proposes a new application for computational reasoning. More specifically, the purpose of this interdisciplinary project is to demonstrate the usefulness of an algorithmic perspective in studies of complex biological systems. We focus on the domain of collective behavior, and demonstrate the benefits of using techniques from the field of theoretical distributed computing in order to e ...
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 2

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An integrative approach to uncover the multilevel regulation of 20S proteasome degradation (20SComplexity)

Start date: Apr 1, 2015, End date: Mar 31, 2020,

For many years, the ubiquitin-26S proteasome degradation pathway was considered the primary route for proteasomal degradation. However, it is now becoming clear that proteins can also be targeted for degradation by a ubiquitin-independent mechanism mediated by the core 20S proteasome itself. Although initially believed to be limited to rare exceptions, degradation by the 20S proteasome is now unde ...
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Relative representation theory and distributions on reductive groups over local fields (RelRepDist)

Start date: Mar 1, 2015, End date: Feb 29, 2020,

One can view the representation theory of a topological group as non-commutative harmonic analysis on the group. For compact groups this view is justified by the Peter-Weyl theorem. The relative representation theory of a group is harmonic analyses on spaces with transitive group action.I work in relative representation theory of reductive (algebraic) groups over local fields, e.g. the general lin ...
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High-Intensity Coherent Nonlinear Optics (HICONO)

Start date: Oct 1, 2015, End date: Sep 30, 2019,

Optical laser-based technologies are a key technology of the 21st century. Extension of the range of scientific and commercial laser applications requires a constant expansion of the accessible regimes of laser operation. Concepts from nonlinear optics, driven with ultra-fast lasers provide all means to achieve this goal. However, nonlinear optics typically suffer from low efficiencies, e.g. if hi ...
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Infrastructure for NMR, EM and X-rays for translational research (iNEXT)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

Structural biology provides insight into the molecular architecture of cells up to atomic resolution, revealing the biological mechanisms that are fundamental to life. It is thus key to many innovations in chemistry, biotechnology and medicine such as engineered enzymes, new potent drugs, innovative vaccines and novel biomaterials.iNEXT (infrastructure for NMR, EM and X-rays for Translational rese ...
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NanoSmells: Artificial remote-controlled odorants (NanoSmell)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

"Despite years of promise, an odor-emitting component in devices such as televisions, phones, computers and more has yet to be developed. Two major obstacles in the way of such development are poor understanding of the olfactory code (the link between odorant structure, neural activity, and odor perception), and technical inability to emit odors in a reversible manner. Here we propose a novel mult ...
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The LHC Battle for Naturalness on the Top Charm Front (TOPCHARM)

Start date: Jul 1, 2014, End date: Jun 30, 2019,

Now that a Higgs-like particle has been discovered naturalness becomes the most pressing and fundamental question within the reach of the Large Hadron Collider (LHC). The main contribution that destabilises the electroweak scale comes from a top-quark loop. The key for addressing the naturalness problem is thus identifying the top partners that are stabilizing the weak scale.We consider the follo ...
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Ultracold Quantum Matter (UQUAM)

Start date: Jul 1, 2013, End date: Jun 30, 2019,

Quantum mechanics is the basis of our understanding of the microscopic world. It is also central to the collective behaviour of matter at low temperatures, leading to unique properties that defy our classical intuition. The comprehension of such ‘quantum matter’ and the ability to master it using a newly developing set of ‘quantum technologies’ is not only of fundamental interest but holds the p ...
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Cellular Destruction Mechanisms that Create New Lives (SPERMDESTRUCT)

Start date: May 1, 2014, End date: Apr 30, 2019,

Apoptosis, the major form of programmed cell death (PCD), is executed by caspases. However, activation of caspases can also promote a variety of vital cellular processes. Furthermore, cell death can sometimes proceed in the absence of apoptotic caspases by triggering alternative cell death (ACD) pathways. The main goal of my proposal is to delineate the molecular mechanisms, pathways and component ...
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microRNAs confer robustness to adult beta–cell identity (MIRNABETAIDENTITY)

Start date: Apr 1, 2014, End date: Mar 31, 2019,

Normal physiology depends on defined functional output of differentiated cells. A century of Developmental–Biology studies revealed diverse mechanisms for differentiation, however once ‘terminally’ differentiated, cells are thought to naïvely stay put. However differentiated cells are surprisingly fragile, for example, phenotypic collapse and de–differentiation of β–cells was recently discovered i ...
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Control of translation efficiency in proliferating and differentiated mammalian cells (TRNAPROLIF)

Start date: Apr 1, 2014, End date: Mar 31, 2019,

Translation maps the transcriptome onto the proteome. It is regulated at the initiation levels and also by mRNA secondary structure, and – our current focus – by the interplay between the mRNA and tRNA pools. Although a lot is known about the mechanics of translation, its effects on physiology, particularly on proliferation and differentiation in mammals presents major open questions.tRNAProlif of ...
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Neutral Quasi-Particles in Mesoscopic Physics (NEUTRAL)

Start date: Mar 1, 2014, End date: Feb 28, 2019,

I propose to study ‘neutral excitations’ in 2d and 1d electronic systems. Such excitations, rarely studied, are unique since they are chargeless but may carry energy. Being byproducts of electron interaction, they come in a few flavors: (i) Downstream modes in composite edge channels of the integer quantum Hall effect (IQHE) regime; (ii) Upstream modes in the fractional quantum Hall effect (FQH ...
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Systematic analysis of the molecular mechanisms underlying axon growth during development and following injury (AXONGROWTH)

Start date: Mar 1, 2014, End date: Feb 28, 2019,

Axon growth potential declines during development, contributing to the lack of effective regeneration in the adult central nervous system. What determines the intrinsic growth potential of neurites, and how such growth is regulated during development, disease and following injury is a fundamental question in neuroscience. Although multiple lines of evidence indicate that intrinsic growth capabilit ...
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