6 European Projects Found
Searched on 125080 European Projects
FINISHED
Surfaces for molecular recognition at the atomic level (SMALL)
Start date: Jan 1, 2010, End date: Dec 31, 2013,
"The overarching aim of the SMALL ITN project is to train Early Stage Researchers in the field of ‘molecular recognition at surfaces’ from fundamental science to novel applications. For this task, SMALL combines European experts from surface science, nanotechnology, theory, chemical synthesis, physics, biology and industry, and thus takes a highly integrated approach to the training. The researche ...
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12
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Tissue Transmigration Training Network (T3Net)
Start date: Sep 1, 2009, End date: Aug 31, 2013,
Cardiovascular and cancer-related diseases are the leading causes of human mortality and disability. The underlying mechanisms originate from chronic interstitial cell activation leading to pathological tissue remodelling and malfunction of cells. These depend on three fundamental processes: cell adhesion, migration, and modulation/degradation of the extracellular matrix (ECM), which together dete ...
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8
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Genomic determinants of inflammation: from physical measurements to system perturbation and mathematical modeling (Model-In)
Start date: Dec 1, 2008, End date: May 31, 2012,
Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement ...
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11
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Conformational dynamics of proteins in the solid state (Protein Dynamics)
Start date: Nov 1, 2009, End date: Oct 31, 2011,
Conformational dynamics are intimately linked to the biological activity of proteins, thereby regulating the essential processes of life. In particular protein motion plays an essential role in catalysis, allowing conformational rearrangements to align key catalytic amino acids and in ligand binding allowing the entry of co-factors into areas that would otherwise be inaccessible. Mobility also pla ...
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1
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The role of the Drosophila tumor suppressor gene p53 in apoptosis and adhesion (p53Adhesion)
Start date: Oct 1, 2008, End date: Sep 30, 2011,
Apoptosis is a form of cell death ubiquitously used in animals, which participates in development and in the adult in defense against potentially dangerous cells. Not surprisingly, deregulation of cell death has severe consequences for the developing organism and adult. Inappropriate cell death is associated with many disorders including degenerative neurological diseases (excess of cell death) an ...
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1
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Identification and characterization of novel human telomere-related biomarkers that aid cancer management by improving patient diagnosis, treatment selection, response monitoring, and drug development (TeloMarker)
Start date: Feb 1, 2008, End date: Jan 31, 2011,
Telomeres are DNA-nucleoprotein structures that protect the ends of human chromosomes through the formation of a ‘cap’ that prevents exonucleolytic degradation, inter- & intra-chromosomal fusion and subsequent chromosomal instability. Telomerase, the ribonucleoprotein enzyme that maintains linear chromosomal DNA ends by the addition of TTAGGG repeats, is completely repressed or present only at low ...
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