Search for European Projects

23 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Beyond genotype to phenotype: how ancestor lifestyle impacts on lifespan variation in descendants (NoisyAgeing)

Start date: Jun 1, 2015, End date: May 31, 2020,

There are many examples in nature where inter-individual variability in life-history traits is exploited as an adaptive strategy. I and others have shown that inter-individual variability in the longevity pathways –and in particular, in stress response genes- has consequences for genetic/environmental phenotypic robustness as well as for lifespan in Caenorhabditis elegans. My main interest is to u ...
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ToWards Immunisations that Last: the Immunology and Gerontology of Helper T cells (TWILIGHT)

Start date: Jun 1, 2015, End date: May 31, 2020,

A major accomplishment of modern society is the extension of human life expectancy. However, this creates a new challenge for medical science, to facilitate healthy ageing. With age, the function of the immune system declines, rendering older people more susceptible to infections and less able to benefit from vaccination. Indeed, improving vaccine efficacy is key to reducing infection-related mor ...
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Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities. (HEP-CAR)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Hepatocellular carcinoma (HCC) is the most common liver malignancy, with an estimated 750,000 new cases and 695,000 deaths per year, rating third in incidence and mortality in the world. Whilst incidence and mortality for other cancers are declining, HCC represents an increasing public health problem in Europe with men having a higher incidence than women. Several liver diseases lead to HCC and be ...
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 9

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Deciphering PI3K biology in health and disease (Phd)

Start date: Nov 1, 2015, End date: Oct 31, 2019,

The Phosphoinositide 3-kinase (PI3K) pathway is at the core of multiple fundamental biological processes controlling metabolism, protein synthesis, cell growth, survival, and migration. This inevitably leads to the involvement of the PI3K signalling pathway in a number of different diseases, ranging from inflammation and diabetes to cancer, with PI3K pathway alterations present in almost 80% of hu ...
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 11

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European Network linking informatics and genomics of helper T cells (ENLIGHT-TEN)

Start date: Oct 1, 2015, End date: Sep 30, 2019,

ENLIGHT-TEN is a European Network Linking Informatics and Genomics of Helper T cells: our mission is to provide cross-disciplinary training in cellular immunology and big data analysis such that we train a new generation of researchers to fully exploit the power of emerging technological platforms. Our network of TEN beneficiaries combines T cell expertise with state-of-the-art technologies such a ...
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 11

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Leading Innovative measures to reach gender Balance in Research Activities (LIBRA)

Start date: Oct 1, 2015, End date: Mar 31, 2019,

The main goals of LIBRA are to implement innovative Gender Equality Plans (GEPs) that will empower women researchers to achieve successful careers in science, remove gender barriers and biases at an institutional level, and raise awareness of gender aspects in the experimental design of pre-clinical research projects. To achieve these goals we will: 1) conduct an initial external assessment of eac ...
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 11

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Chromosome structure and genome organization in early mammalian development (DEVOCHROMO)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"The spatial organization of the genome inside the cell nucleus is tissue-specific and has been linked to several nuclear processes including gene activation, gene silencing, genomic imprinting, gene co-regulation, genome maintenance, DNA replication, DNA repair, chromosomal translocations and X chromosome inactivation. In fact, just about any nuclear/genome function has a spatial component that h ...
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 1

 FINISHED 

Dissecting the epigenetic control of totipotency. (TOTIPOTENCY2014)

Start date: Jan 1, 2016, End date: Dec 31, 2017,

One of the most critical epigenetic and chromatin remodelling processes in mammalian development occurs shortly after fertilization restoring totipotency. Due to limited cell numbers and lack of experimentally tractable systems, the mechanisms and regulation of this developmental stage are poorly understood. This proposal will provide important mechanistic insights into the epigenetic control of e ...
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Mitotis-induced entosis and its role in cancer (ENTOSIS2013)

Start date: Oct 1, 2014, End date: Apr 1, 2017,

...significance of mitosis-induced entosis in human cancer4) Relevance of entosis to anti-mitotic cancer therapiesThe host lab is one of a few groups globally with experience in studying entosis and the Babraham Institute provides a rich research environment, with state of the art equipment. I will bring my key preliminary data and >10 years experience in biochemical/cell biological studies to aid th ...
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SYSTEMS BIOLOGY OF PATHWAYS INVOLVING BRAIN AGEING (AGEDBRAINSYSBIO)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

In spite of valuable approaches applied to get a broad understanding of genetic, epidemiologic and molecular and system-level biological principles of human aging, cognitive decline remains as one of the greatest health challenges of the old age, with nearly 50% of adults over 85 afflicted of Alzheimer’s disease. Furthermore, drug development has not performed as expected in clinical trials, at le ...
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 15

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Crosstalk of epithelial lymphocytes and microbiota in influencing immunity and metabolism (Epithelial_Immunol)

Start date: Nov 1, 2011, End date: Oct 31, 2016,

This proposal aims to study the interactions between specialised cells of the immune system, the intra-epithelial cells (IELs) which are ideally positioned in close proximity of the epithelial cells, and the intestinal microbiota.It aims to provide insights into how IELs are able to maintain tolerance to beneficial bacteria while enhancing immune responses against undesirable ones. This will be ac ...
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A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Start date: Oct 1, 2011, End date: Sep 30, 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)

Start date: Jan 1, 2011, End date: Jun 30, 2016,

"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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 18

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Studying Physiology and Pathology of Imprinted Genes to understand the role of Epigenetic Mutations in Human Disease (INGENIUM)

Start date: Apr 1, 2012, End date: Mar 31, 2016,

"The aim of this ITN is to promote research and training in the field of epigenetics associated with human disease. Expression of imprinted genes is mono-allelic and gamete of origin-dependent. This is due to different epigenetic modifications present on the maternal and paternal chromosomes. Failure in normal establishment, maintenance or erasure of these marks results in gene dosage dysregulatio ...
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Epigenetics towards systems biology (EPIGENESYS)

Start date: Oct 1, 2010, End date: Mar 31, 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

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"Identification of whether, in which aspects and by which function, a RNA binding protein, KH-type splicing regulatory protein governs development and function of B cell, a type of white blood cell" (3W-RGB)

Start date: Jul 1, 2013, End date: Jun 30, 2015,

"The immune system is a biological defence against diseases including virus and bacterial infections. A type of white blood cell, B cell, is causative for production of antibodies, key effectors to identify and neutralize viruses or bacteria. B cell can produce high affinity antibodies rapidly upon re-exposure to the same infectious agent, making B cell a key player for immunological memory, a pri ...
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Protein Binders for Characterisation of Human Proteome Function: Generation, Validation, Application (AFFINOMICS)

Start date: Apr 1, 2010, End date: Mar 31, 2015,

The Affinomics programme aims to leverage existing efforts in Europe to generate large-scale resources of validated protein-binding molecules (‘binders’) as affinity reagents for characterisation of the human proteome and to apply them in comprehensive structural and functional analyses of protein expression, interactions and complexes. Proteome targets will be focused on five categories of inter- ...
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Synaptic Systems: dissecting brain function in health and disease (SYNSYS)

Start date: Jul 1, 2010, End date: Dec 31, 2014,

Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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 19

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Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease (LipidomicNet)

Start date: May 1, 2008, End date: Oct 31, 2012,

Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quan ...
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 27

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a Study of the Epigenetic Alterations that Result in Cardiac Hypertrophy (SEARCH)

Start date: Apr 1, 2010, End date: Mar 31, 2012,

"Heart failure is a major cause of mortality and morbidity, and often the consequence of pathological cardiac hypertrophy. Upon entering hypertrophy, cells undergo a vast transcriptional remodelling, with thousands of genes being either up- or down-regulated. In the last years it became evident that epigenetic modifications are an important determinant of transcriptional changes, and several lines ...
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Analysis of the roles of the TRPV2 calcium channel in inflammation (TRPV2PI3KMacrophage)

Start date: Mar 2, 2009, End date: Sep 1, 2011,

Macrophages are key players in the front line of our immune system, responsible primarily for the recognition and destruction of bacterial and fungal pathogens. However, they are also involved in various inflammatory pathologies. Membrane receptors of chemokines control many aspects of macrophages functions by stimulating various 2nd messenger systems, important amongst these are PI3Ks and Ca2+. H ...
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Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)

Start date: Feb 1, 2008, End date: Jan 31, 2011,

The Preparatory Phase for a pan-European Biobanking and Biomolecular Resources Research Infrastructure (BBMRI) will focus on technical, legal, governance, and financial issues to • prepare to construct BBMRI, building on existing biobanks, resources and technologies, specifically complemented with innovative components and properly embedded into European scientific, ethical, legal and societal fra ...
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The role of Kcnk9 imprinting in development and disease (Kcnk9 imprinting)

Start date: Jul 1, 2008, End date: Jun 30, 2010,

Genomic imprinting is the epigenetic marking of a subset of genes which results in monoallelic or predominant expression of one of the two parental alleles according to their parental origin. In my previous work, I discovered the imprinted expression of the Kcnk9 gene in mice and humans. Kcnk9 is a member of the two-pore (2P)-domain K+ channel family and encodes for the potassium channel protein T ...
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