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Over 40 European Projects Found

Searched on 125080 European Projects

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Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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 25

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Post-transcriptional Regulation of Germinal Center B Cell Responses in Immunity and Disease (GCB-PRID)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

Antibodies secreted by B cells of the adaptive immune system establish an essential barrier against bacteria and viruses and their presence is the hallmark of protective vaccinations. B cells are licensed for their tasks during germinal center (GC) reactions and differentiation into antibody-secreting plasma cells. Unfortunately, B cell-derived autoantibodies and proinflammatory cytokines can caus ...
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 2

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Dissecting the role of the ubiquitin proteasome system in the pathogenesis and therapy of B-cell malignancies (BCM-UPS)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

B-cell malignancies are characterized by high levels of genomic instability, which critically contribute to their pathogenesis and evolution. Recently, the fundamental role of the ubiquitin proteasome system (UPS) in maintaining genome integrity has been appreciated. Two major new therapeutic modalities in B-cell malignancies, proteasome inhibitors and imunomodulatory drugs (IMiDs), target the UPS ...
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 2

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Individualised medicine in chronic inflammatory skin diseases (IMCIS)

Start date: Jul 1, 2016, End date: Jun 30, 2021,

More than 100 million EU citizens suffer from chronic inflammatory skin diseases such as psoriasis and atopic eczema (AE). The diseases imply a devastating life quality similar to that of cancer, and cause direct socio-economic costs in the magnitude of 100 billion Euro each year in the EU. Despite all efforts, psoriasis and AE remain undertreated and the concept of individualised (also called pre ...
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 2

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Magnetic resonance imaging platform for probing fat microstructure (ProFatMRI)

Start date: Apr 1, 2016, End date: Mar 31, 2021,

Metabolic syndrome and osteoporosis are the two metabolic diseases with the highest and most rapidly growing prevalence, transforming them into a major global health and socioeconomic concern. Metabolic syndrome can be diagnosed with established biomarkers, but the selection of optimal prevention strategies for each individual patient is still problematic. Osteoporosis can be treated, but its curr ...
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 2

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Next-generation in vivo models for improved pancreatic cancer therapies (PanCaT)

Start date: Feb 1, 2016, End date: Jan 31, 2021,

Maintenance and drug resistance of pancreatic ductal adenocarcioma (PDAC) depends on cancer cell intrinsic mechanisms and a stroma that supports tumor growth. Mouse models of human PDAC have provided important insights into the evolution of this highly lethal tumor, but there are no models that allow secondary genetic manipulation of autochthonous tumors, the tumor microenvironment or the metastat ...
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 2

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Small vessel diseases in a mechanistic perspective: Targets for InterventionAffected pathways and mechanistic exploitation for prevention of stroke and dementia (SVDs-at-target)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

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Light induced spatially EXact and genetically encoded labeling of immune cells for monitoring of lOng Distance and Ultra-compartment Shuttling during autoimmunity and chronic inflammation (EXODUS)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

The incidence of autoimmune diseases including multiple sclerosis is dramatically increasing. While there is a genetically defined “bedrock” susceptibility to develop T cell mediated autoimmunity, environmental cues likely determine the threshold for disease development. Yet, little is known on how environmental cues sensed at body/environment interfaces are translated into immunopathology in dist ...
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 2

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Individualized treatment planning in chronic back pain patients by advanced imaging and multi-parametric biomechanical models (iBack)

Start date: Jun 1, 2015, End date: May 31, 2020,

Chronic back pain is a major burden and source of disability worldwide. It is primarily attributed to biomechanical factors. In elderly patients, osteoporosis complicates the biomechanical scenario. Surgery is often required to treat instability-related pain and to restore the balance of the spine. However, when and how to perform surgery remains a highly subjective decision based on the surgeon’s ...
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 3

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Autologous Stem Cell Seeded Tissue Engineered Trachea (TETRA)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

CLINICAL PROBLEM AND UNMET NEEDThere are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic trac ...
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 14

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Platform for Open Development of Systems of Artificial Intelligence (Bonseyes)

Start date: Dec 1, 2016, End date: Nov 30, 2019,

The Bonseyes project aims to develop a platform consisting of a Data Marketplace, Deep Learning Toolbox, and Developer Reference Platforms for organizations wanting to adopt Artificial Intelligence in low power IoT devices (“edge computing”), embedded computing systems, or data center servers (“cloud computing”). It will bring about orders of magnitude improvements in efficiency, performance, reli ...
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 15

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A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia (TRIMAGE)

Start date: Dec 1, 2013, End date: Nov 30, 2018,

"Schizophrenia is a severe mental disorder that manifests early in life and imposes a high social and economic burden on European societies. An imaging tool that enables the diagnosis of schizophrenia during early development is extremely desirable and is requested by the clinical community in order to make the management of the disease more effective.TRIMAGE aims to optimise and validate an integ ...
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 11

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Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer (CAM-PAC)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di ...
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 18

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implementAtion anD OPeration of the gateway for healTh into BBMRI-ERIC (ADOPT BBMRI-ERIC)

Start date: Oct 1, 2015, End date: Sep 30, 2018,

"BBMRI-ERIC: the Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium, aims to establish, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical research. The ADOPT BBMRI-ERIC proposal aims at ...
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 22

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Schizophrenia Psychological Interventions Network Meta-Analysis of randomized evidence (SPIN-MA)

Start date: Oct 1, 2016, End date: Sep 30, 2018,

...isions according to an evidence based medicine approach. This addresses several EU programs’ aims. I will be hosted at the Department of Psychiatry and Psychotherapy of Klinikum rechts der Isar der Technischen Universität München, under the supervision of Professor Stefan Leucht, who has outstanding expertise both in the field of schizophrenia treatment and in the methodology of NMA. A partner or ...
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 2

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Statistical multi-Omics UNDerstanding of Patient Samples (SOUND)

Start date: Sep 1, 2015, End date: Aug 31, 2018,

Bioinformatic analysis is the biggest bottleneck in many genomic medicine projects. Our objective is to enable researchers to dramatically increase statistically informed use of personal multi-omic data in medicine. Soon, multiple types of omic technologies will be applied to 100,000s of patient-derived samples, with the three-stage goal of better understanding disease biology, discovery of new in ...
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 11

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Regulation and Function of CARD9 / BCL10 / MALT1 Signalosomes in Innate Immunity and Inflammation (CBM-Innate)

Start date: Feb 1, 2013, End date: Jan 31, 2018,

Acute inflammation is a response to infection or tissue damage that is critical for host protection and tissue homeostasis. However, deregulated or chronic inflammation is harmful to the host and can cause multiple diseases including inflammatory bowel disease, rheumatoid arthritis, cardiovascular diseases, neuroinflammatory disease and cancer. Cells of the innate immune system sense microbial or ...
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 1

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Reverse engineering the vertebrate molecular machinery for magnetic biomineralisation (MagnetoGenetics)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

In order to understand distributed biological networks and invent effective molecular therapies, we need to be able to image and control molecular processes across entire live organisms.Although an arsenal of genetically encoded fluorescent sensors and light-activated proteins has recently been developed to visualize and manipulate cellular activity, these methods all suffer from the poor penetrat ...
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 2

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iRhom2 in neuroinflammation and pathogenesis of Alzheimer’s Disease (iRhom2 in AD)

Start date: Dec 1, 2015, End date: Nov 30, 2017,

Alzheimer’s disease (AD) is the most common form of dementia in the elderly, a syndrome characterized by loss of memory and cognitive decline. AD has a dramatic socio-economical impact that is foreseen to worsen in the near future unless a cure is found. The pathology is triggered by the accumulation of Aβ oligomers that begins a cascade culminating with the formation of neurofibrillary tangles wi ...
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 1

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Opportunities for professional development in below the knee vascular disease

Start date: Nov 1, 2015, End date: Oct 31, 2017,

Societatea Romana de Chirurgie Vasculara is a private institution, active in the educational and social fields. We aim to promote the culture of lifelong learning through active involvement of all community members in developing a coherent strategy for implementing the concept and practice of “learning throughout life”. This strategy represents the success factor for the transition of the Romanian ...
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 5

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Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope (EU-CERT-ICD)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and cos ...
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 27

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Multimodal Imaging of Neurological Disorders (MINDView)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

The key concept behind this proposal is the development of a very high resolution and high efficiency brain dedicated Positron Emission Tomograph (PET) imager that can visualize neurotransmitter pathways and their disruptions in the quest to better diagnose and consequently to better treat schizophrenia. In addition, the plan is for this compact PET imager to be integrated with a Magnetic Resonanc ...
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 10

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Multimodal Molecular Imaging (MUMI)

Start date: Jun 1, 2012, End date: May 31, 2017,

"Imaging has become an integral part of diagnosis and staging of disease. This proposal aims at the development if innovative imaging methods for the visualization and quantitative assessment of biologic processes in-vivo. The simultaneous MR/PET data acquisition will be employed o integrate structural, physiologic and molecular information for the phenotyping of human disease and therapeutic deci ...
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 1

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Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure (OptimEx)

Start date: Oct 1, 2013, End date: Mar 31, 2017,

More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, “diastolic heart failure”). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medic ...
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 9

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Modeling congenital heart disease (CHD) in ISL1+ cardiovascular progenitors from patient-specific iPS cells (CHD-iPS)

Start date: Mar 1, 2011, End date: Feb 28, 2017,

Tetralogy of Fallot (TOF) is the most common congenital heart disease (CHD) occurring 1 in 3000 births. Genetic studies have identified numerous genes that are responsible for inherited and sporadic forms of TOF, most of which encode key molecules that are part of regulatory networks controlling heart development. The identification of two populations of cardiac precursors, one exclusively forming ...
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 1

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Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)

Start date: Mar 1, 2012, End date: Feb 28, 2017,

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
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 39

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BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Start date: Feb 1, 2013, End date: Jan 31, 2017,

In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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 36

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Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury (MIP-DILI)

Start date: Feb 1, 2012, End date: Jan 31, 2017,

The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test sys ...
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 29

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Mitochondrial European Educational Training (MEET)

Start date: Jan 14, 2013, End date: Jan 13, 2017,

"The expanding diversification and specialization of knowledge and the growing complexity of contemporary research in translational research warrant the creation of cooperative multi-disciplinary networks including both basic and medically oriented expertise. This notion is especially true for Mitochondrial Medicine which aims at understanding the physiopathological mechanisms sharing the features ...
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 10

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The role of ROS/RNS during inflammation-associated and sporadic carcinogenesis (ROSCAN)

Start date: Oct 1, 2011, End date: Sep 30, 2016,

"A link between inflammation and cancer has been suspected over a long period of time and in recent years genetic evidence supporting such notion could be obtained. Several signaling pathways, such as NF-κB and STAT3, could be identified by our group as well as other groups to play important roles during tumor promotion and progression. Chronic inflammation leads to the formation of reactive oxyge ...
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 2

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Improving HSCT By Validation Of Biomarkers & Development Of Novel Cellular Therapies (CELLEUROPE)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

Novel transplant regimens are currently being developed to improve beneficial GvL effects and reduce GvHD and infections via several new forms of cellular therapies. This newly emerging supra-disciplinary field of cellular therapy and regenerative medicine is also being used to improve outcomes in autoimmune disease (such as Rheumatoid Arthritis) and cancers. The goal of this research programme is ...
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 13

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OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) (OPTiMiSE)

Start date: Feb 1, 2010, End date: Jul 31, 2016,

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project wi ...
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 25

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Semantic Infostructure interlinking an open source Finite Element tool and libraries with a model repository for the multi-scale Modelling and 3d visualization of the inner-ear (SIFEM)

Start date: Feb 1, 2013, End date: Jan 31, 2016,

The clinical evidence indicates that the number of people with all levels of hearing impairment and hearing loss is rising mainly due to a growing global population and longer life expectancies. Hearing loss caused by pathology in the cochlea or the cochlear nerve is classified as sensorineural hearing loss. The study of the normal function and pathology of the inner ear has unique difficulties as ...
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 11

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Building data bridges between biological and medical infrastructures in Europe (BIOMEDBRIDGES)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

The ESFRI infrastructures in Biological and BioMedical Sciences face substantial challenges in accessing and sharing data and resources. The BioMedBridges consortium brings together the six established ESFRI infrastructures with common goals to define, implement and deliver data interoperability across the biological and biomedical domains.The first objective is to ensure that interoperable stand ...
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 26

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ATMP GMP Open Access Research Alliance - AGORA (AGORA)

Start date: Sep 1, 2013, End date: Oct 31, 2015,

We propose an academic & industrial partnership to facilitate safe and effective delivery of new advanced therapy medicines within the framework of the relevant EU regulations which our previous FP7 funded project have identified as creating unanticipated barriers to development of this field. Over 80% of advanced therapy medicines (ATMPs) trials in the EU are academic investigator led and sponsor ...
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 8

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Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to hal ...
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 14

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Biohybrid templates for peripheral nerve regeneration (Biohybrid)

Start date: Oct 1, 2011, End date: Sep 30, 2015,

The BIOHYBRID consortium was build up with the overall aim to develop, in a preclinical perspective, an innovative biohybrid artificial nerve device for the regenerative treatment of traumatic injuries of peripheral nerves. This consortium consists of three active and well integrated SMEs as well as seven academic partners that are recognised leaders in the scientific areas of interest for this pr ...
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 10

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Understanding chronic pain and improving its treatment (EUROPAIN)

Start date: Oct 1, 2009, End date: Sep 30, 2015,

We will establish an international team of leading researchers and clinicians (EuroPain) to undertake multidisciplinary translational research which will: 1) increase the understanding of chronic pain mechanisms; 2)facilitate the development of novel analgesic drugs; and 3) improve the treatment of chronic pain patients.Nineteen researchers drawn from the London Pain Consortium, the Danish Pain Re ...
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 29

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Future Internet Social and Technological Alignment Research (FI-STAR)

Start date: Apr 1, 2013, End date: Sep 30, 2015,

FI-STAR will establish early trials in the Health Care domain building on Future Internet (FI) technology leveraging on the outcomes of FI-PPP Phase 1. It will become self-sufficient after the end of the project and will continue on a sustainable business model by several partners. In order to meet the requirements of a global Health industry FI-STAR will use a fundamentally different, "reverse" c ...
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Novel multimodal endoscopic probes for simultaneous PET/ultrasound imaging for image-guided interventions (ENDOTOFPET-US)

Start date: Jan 1, 2011, End date: Jun 30, 2015,

In the frame of this project it is proposed to define and build a bi-modal PET-US (Positron Emission Tomography and Ultrasound) endoscopic probe combining in a miniaturized system a fully digital, 200ps time resolution Time of Flight PET detector head (TOF-PET) coupled to a commercial ultrasound (US) assisted biopsy endoscope and to launch the first steps of clinical validation.The project address ...
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