5 European Projects Found
Searched on 125080 European Projects
FINISHED
Functional Role of the HLA-DR15 Haplotype in Multiple Sclerosis (HLA-DR15 in MS)
Start date: Jan 1, 2015, End date: Dec 31, 2019,
Multiple sclerosis (MS) is a prototypic CD4+ T cell-mediated autoimmune disease that damages the central nervous system. MS affects young adults and women twice as often as men. Neurological deficits cause substantial disability at an early age with high socioeconomic impact.Both a complex genetic trait and environmental factors are involved in MS etiology. Similar to other autoimmune diseases it ...
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2
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Systems Biology of T-cell Activation in Health and Disease (SYBILLA)
Start date: Apr 1, 2008, End date: Sep 30, 2013,
T-cell activation, whether induced by pathogens or auto-antigens, is a complex process relying on multiple layers of tightly controlled intracellular signalling modules that form an intricate network. Defects in this network can cause severe and chronic disorders such as autoimmune diseases. Although 5% of the population suffer from these diseases, only a few therapeutic treatments are available. ...
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22
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PROteomics SPECification in Time and Space (PROSPECTS)
Start date: Apr 1, 2008, End date: Mar 31, 2013,
"Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future atte ...
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11
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"Systems-Level, Multi-layer Understanding of Cellular Responses to Ionizing Radiation" (TRIREME)
Start date: Jan 1, 2009, End date: Dec 31, 2011,
"The TRIREME project aims at developing and implementing a multidisciplinary strategy for a systems-level analysis of a cornerstone of cellular homeostasis – the DNA damage response (DDR). The DDR is a complex signaling network that is responsible for maintaining the stability and integrity of the cellular genome in the face of DNA damage. DDR defects underlie acute and chronic forms of human ailm ...
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6
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Analysis of the kinetochore architecture and dynamics using a mass spectrometry based integrative structural approach (Kinetochore Map)
Start date: Jan 1, 2010, End date: Dec 31, 2011,
A mechanistic understanding of a living cell requires the characterization of the architecture and dynamic assembly of its macromolecular complexes. The proposed project describes a novel integrative approach to determine the topology of protein networks and higher order assemblies using chemical crosslinking, state of the art mass spectrometry (MS) and cryo-electron tomography (cryo-ET). This MS ...
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