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Enigma – Histone Deacetylase protein complex controls cardiac hypertrophy (ENIGMA)
Start date: Jul 1, 2012, End date: Jun 30, 2016,
"A variety of cardiovascular disorders provoke the heart to enlarge through hypertrophic growth of cardiomyocytes, resulting in heart failure and sudden death. Based on in vivo and in vitro models of cardiac hypertrophy, it is apparent that histone-modifying enzymes act as key regulators of cardiac growth. Although their upstream regulation has been studied, the mechanism whereby class IIa Histone ...
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