3 European Projects Found
Searched on 125080 European Projects
FINISHED
Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) (NET4CGD)
Start date: Dec 1, 2012, End date: May 31, 2018,
This project is focused on the clinical development of a new orphan drug that can rapidly become a new treatment option for patients with the X-linked form of chronic granulomatous disease (X-CGD). This rare primary immune deficiency of phagocytes is caused by mutations in the gp91phox gene. Affected patients are highly-susceptible to infections and develop inflammatory granulomas. Several member ...
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11
Partners Participants
FINISHED
The role of ROS/RNS during inflammation-associated and sporadic carcinogenesis (ROSCAN)
Start date: Oct 1, 2011, End date: Sep 30, 2016,
"A link between inflammation and cancer has been suspected over a long period of time and in recent years genetic evidence supporting such notion could be obtained. Several signaling pathways, such as NF-κB and STAT3, could be identified by our group as well as other groups to play important roles during tumor promotion and progression. Chronic inflammation leads to the formation of reactive oxyge ...
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2
Partners Participants
FINISHED
Persisting Transgenesis (PERSIST)
Start date: Jan 1, 2009, End date: Jun 30, 2013,
"For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize ...
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