Search for European Projects

9 European Projects Found

Searched on 125080 European Projects

 FINISHED 

To Notch up a broken heart (StressFate)

Start date: May 1, 2014, End date: Apr 30, 2018,

Heart failure is a major health issue and a cause of death and disability. The endogenous regenerative capacity of the heart is too weak to recover from damage and instead the heart repairs damage by synthesis of a scar tissue leading to functional deterioration. To improve cardiac regeneration, stem cell therapies and material-based approaches have been developed but up till now with limited succ ...
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A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co-morbidities; hypertriglyceridemia and low HDL-cholesterol (RESOLVE)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

"Through combining basic pre-clinical and clinical research, network analysis and computational modelling, RESOLVE aims at resolving the disturbed dynamics and mechanisms underlying the high triglyceride (HTG) and low high-density lipoprotein cholesterol (HDL-C) phenotype and insulin resistance in patients with metabolic syndrome (MetS) and its associated co-morbidities (cardiovascular disease, CV ...
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Engineering protein switches: sensors and regulators for biology and diagnostics (SwitchProteinSwitch)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

... specific application areas, modeling tools will be developed that allow quantitative analysis and prediction of conformational stabilities for modular protein switches. The availability of these robust and generally applicable engineering strategies will proof beneficial to many areas of life sciences, providing essential tools for intracellular imaging, synthetic biology, and molecular diagnosti ...
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 1

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Next-generation integrated MNBS-platform for instant diagnostics with single-molecule resolution (NextDx)

Start date: Dec 1, 2012, End date: Nov 30, 2015,

A spearhead function that lies within the promise of MNBS technologies is the rapid and sensitive detection of biomarker molecules in raw biological samples. However, it has been very difficult to realize the promise due to two key challenges:the signal-over-background challenge, i.e. many biomarkers have very low concentrations and real-life biological samples generate very high background signal ...
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 7

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Functional prognosis simulation of patient-specific spinal treatment for clinical use (MySPINE)

Start date: Mar 1, 2011, End date: Aug 31, 2014,

Description Improving the treatment of lower back painThe MySpine project aims to improve the treatment of lower back pain. Nowadays treatment and prognosis of spinal disc degeneration are still based on trial and error decisions from the surgeon, leading to numerous post treatment complications and eventual morbidity. MySpine is working ...
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 9

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Using chemical-biology to synthesis and study nuclear receptor proteins (CHEMbioNMR)

Start date: Apr 1, 2012, End date: Mar 31, 2014,

...synthetic chemistry with the spectrum of micro- and molecular biology techniques, thus important challenges in medicine can be addressed in revolutionary new ways. This innovative methodology allows problems associated with studying diseases and designing novel drug-like molecules to be tackled in a unique approach. A recent example is the combination of synthetic carbohydrate chemistry with paras ...
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Disc-degeneration linked pathologies: novel biomarkers and diagnostics for targeting treatment and repair (Genodisc)

Start date: Mar 1, 2008, End date: Feb 28, 2013,

Disorders arising from degeneration of the intervertebral disc are an enormous clinical and financial burden on European societies. Most of the burden arises from 10% of patients who become chronically disabled. Any factor which will improve treatment of back pain sufferers or prevent development of chronic disability would have an important impact both on society and in improving quality of life ...
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 10

 FINISHED 

Osteoporotic Virtual Physiological Human (VPHOP)

Start date: Sep 1, 2008, End date: Oct 31, 2012,

...entional diagnostic imaging methods that makes it possible, in a clinical setting, to predict for each patient the strength of his/her bones, how this strength is likely to change over time, and the probability that the he/she will overload his/her bones during daily life. With these three predictions, the evaluation of the absolute risk of bone fracture will be much more accurate than any predic ...
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Image-controlled Ultrasound-induced Drug Delivery (SonoDrugs)

Start date: Nov 1, 2008, End date: Oct 31, 2012,

The demographic changes in Europe towards an aging society will coincide with increasing morbidity of the population. European citizens need improved access to state-of-the-art medical care especially in oncology and cardiology, while keeping expenditures on healthcare affordable. New therapeutic options such as externally triggered local drug release at the diseased area hold promise to solve urg ...
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