2 European Projects Found
Searched on 125080 European Projects
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The MEtabolic Road to DIAstolic Heart Failure (MEDIA)
Start date: Jan 1, 2011, End date: Jun 30, 2016,
More than 50% of heart failure (HF) patients present without a major deficit of left ventricular (LV) systolic function and are presumed to suffer from diastolic HF (DHF) because diastolic LV distensibility is usually impaired in these patients. The vast majority (~80%) of DHF patients is exposed to metabolic risk factors. The MEDIA consortium therefore investigates:1) how metabolic derangements c ...
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Sarcomere based Signals in Muscle Remodelling (SARCOSI)
Start date: Apr 1, 2012, End date: Mar 31, 2016,
The sarcomere is the structural unit of striated muscle tissues where thick and thin filaments cooperate to achieve muscle contraction. Recently it is becoming increasingly clear that sarcomeres have in addition to muscle contraction also important signaling functions: Stretch and strain sensing signalosomes are assembled by the giant muscle proteins titin and nebulin, that in turn are embedded in ...
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