3 European Projects Found
Searched on 125080 European Projects
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Natural course, pathophysiology, models for early diagnosis, prevention and innovative treatment of TNF Receptor Associated Periodic Syndrome TRAPS with application for all hereditary recurrent fevers (EUROTRAPS)
Start date: Apr 1, 2008, End date: Sep 30, 2011,
The TNF Receptor Associated Syndrome (TRAPS) is a rare disease of innate immunity, caused by mutations in TNFR1. It is characterised by recurrent bouts of fever and pain and mainly affects patients of European ancestry. The development of renal amyloidosis in up to 20% of cases makes it a potentially fatal disease. Corticosteroids and anti-TNF therapeutics have not been consistently effective in c ...
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9
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European initiative to improve knowledge, treatment and survival of haemophagocytic syndromes in children (CureHLH)
Start date: Jun 1, 2008, End date: May 31, 2011,
Haemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening inherited immune disorder of early childhood characterised by an uncontrolled immune response. Three disease causing genes have been identified in about half of the patients. Diagnosis is difficult, pathophysiology poorly understood, and treatment unsatisfactory with about 40% of the children dying from treatment failure or t ...
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9
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FINISHED
Innate immunity crosstalk in immunoregulation (INNATE_CROSSTALK)
Start date: Jul 1, 2008, End date: Jun 30, 2009,
"Innate immunity is believed to protect mammalians from most infections. In the majority of cases, the quick responses by innate effector cells clear the infection before adaptive immunity develops. In recent years it has become evident that the early crosstalk between different innate immune cells also has a role in the development of adaptive immunity. In particular, NK-dendritic cell (DC) inter ...
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