5 European Projects Found
Searched on 125080 European Projects
FINISHED
Beta-cell function in juvenile diabetes and obesity (Beta-JUDO)
Start date: Feb 1, 2012, End date: Nov 30, 2016,
The number of individuals with obesity and type 2 diabetes mellitus (T2DM) is increasing. An alarming aspect is decline in age of onset of T2DM, which is coupled to rise in childhood obesity. Accentuated insulin secretion is observed early in young obese individuals. In many subjects insulin hypersecretion is evident when insulin sensitivity is essentially normal. Based on these observations we pr ...
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12
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Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems (DETECTIVE)
Start date: Jan 1, 2011, End date: Dec 31, 2015,
"Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes. An integrated research strategy for the replacement of animal tests needs to comprise the development of biomarkers of long-term toxicity in human target cells. To this aim, the DETECTIVE project will set up a scr ...
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15
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"Myasthenias, a group of immune mediated neurological diseases: from etiology to therapy." (FIGHT-MG)
Start date: Dec 1, 2009, End date: May 31, 2014,
"Myasthenia Gravis (MG) is a heterogeneous rare autoimmune neurological disease affecting the neuromuscular junction (NMJ). The molecular events causing and maintaining MG are still unknown and current treatments do not lead to remission and entail considerable side-effects stressing the need for improved therapies. We will address the: 1. Natural course of disease: determine factors associated wi ...
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13
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Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)
Start date: Apr 1, 2008, End date: Sep 30, 2013,
"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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34
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Neurotransmitter Cys-loop receptors: structure, function and disease (NeuroCypres)
Start date: Feb 1, 2008, End date: Jul 31, 2012,
Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disord ...
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